Results 21 to 30 of about 221,644 (354)
Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. [PDF]
, 2015 Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders.
Ginsberg, Mark H +6 more
core +2 more sources
Integrins, cancer and snake toxins (mini-review)
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj +1 more source
Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin [PDF]
, 2016 Functional cross-talk between Tie2 and Integrin signaling pathways is essential to coordinate endothelial cell adhesion and migration in response to the extracellular matrix, yet the mechanisms behind this phenomenon are unclear.
Barton, William A. +3 more
core +4 more sources
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
Nature Communications, 2017 Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (
Mitasha Bharadwaj +7 more
doaj +1 more source
F1000Research, 2017 While integrins were originally discovered as cell adhesion receptors, recent studies have reinforced the concept that integrins have central roles in cancer that extend far beyond controlling cell adhesion and migration.
Whitney Longmate, C Michael DiPersio
doaj +1 more source
The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
Frontiers in Cell and Developmental Biology, 2022 Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells ...
Hao Sun +2 more
doaj +1 more source
Components of cell-matrix linkage as potential new markers for prostate cancer [PDF]
, 2011 Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment.
Eble, Johannes Andreas, Navdaev, Alexey
core +2 more sources
Integrin activation states and eosinophil recruitment in asthma
Frontiers in Pharmacology, 2013 Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the ...
Mats W Johansson, Deane F Mosher
doaj +1 more source
The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering [PDF]
, 2014 Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a ...
Bouaouina, Mohamed +7 more
core +4 more sources
Cells, 2022 Smooth muscle cells (SMCs), present in the media layer of blood vessels, are crucial in maintaining vascular homeostasis. Upon vascular injury, SMCs show a high degree of plasticity, undergo a change from a “contractile” to a “synthetic” phenotype, and ...
Manish Jain, Anil K. Chauhan
doaj +1 more source