Results 21 to 30 of about 130,772 (312)
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
Nature Communications, 2017 Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (
Mitasha Bharadwaj +7 more
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BMB Reports, 2014 Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate.
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F1000Research, 2017 While integrins were originally discovered as cell adhesion receptors, recent studies have reinforced the concept that integrins have central roles in cancer that extend far beyond controlling cell adhesion and migration.
Whitney Longmate, C Michael DiPersio
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The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells
Frontiers in Cell and Developmental Biology, 2022 Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells ...
Hao Sun +2 more
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Journal of Cell Science, 2009 A successful immune response depends on the capacity of immune cells to travel from one location in the body to another–these cells are rapid migrators, travelling at speeds of μm/minute. Their ability to penetrate into tissues and to make contacts with other cells depends chiefly on the β2 integrin known as LFA-1.
Lena Svensson +6 more
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Frontiers in Molecular Biosciences, 2022 The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly,
Houcemeddine Othman +10 more
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Integrins and the Myocardium [PDF]
Circulation Research, 2001 Abstract —Extracellular matrix provides a structural, chemical, and mechanical substrate that is essential in cardiac development, growth, and responses to pathophysiological signals. Transmembrane receptors termed integrins provide a dynamic interaction of environmental cues and intracellular events.
Robert S. Ross, Thomas K. Borg
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Integrin activation states and eosinophil recruitment in asthma
Frontiers in Pharmacology, 2013 Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the ...
Mats W Johansson, Deane F Mosher
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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Cell Communication and Signaling, 2023 Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain.
Siyi Li +4 more
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Integrins and Integrin-Associated Proteins in the Cardiac Myocyte [PDF]
Circulation Research, 2014 Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers,
Israeli-Rosenberg, Sharon +3 more
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