Results 31 to 40 of about 130,772 (312)
Integral Roles for Integrins in γδ T Cell Function
Frontiers in Immunology, 2018 Integrins are adhesion receptors on the cell surface that enable cells to respond to their environment. Most integrins are heterodimers, comprising α and β type I transmembrane glycoprotein chains with large extracellular domains and short cytoplasmic ...
Gabrielle M. Siegers
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Molecular Therapy: Oncolytics, 2022 High-grade gliomas (HGGs) are lethal central nervous system tumors that spread quickly through the brain, making treatment challenging. Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) interactions, cellular adhesion ...
Kimberly Ann Rivera-Caraballo +4 more
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Cells, 2022 Smooth muscle cells (SMCs), present in the media layer of blood vessels, are crucial in maintaining vascular homeostasis. Upon vascular injury, SMCs show a high degree of plasticity, undergo a change from a “contractile” to a “synthetic” phenotype, and ...
Manish Jain, Anil K. Chauhan
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BMC Research Notes, 2017 Objective Adhesion of cells to the extracellular matrix is facilitated by integrin receptors. We recently found that a nanoscale organization of plasma membrane located integrins containing the β1 subunit is responsible for an enhanced radio-resistance ...
Laura Babel +4 more
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Viruses, 2021 Although ACE2 (angiotensin converting enzyme 2) is considered the primary receptor for CoV-2 cell entry, recent reports suggest that alternative pathways may contribute. This paper considers the hypothesis that viral binding to cell-surface integrins may
Lee Makowski +2 more
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Integrins and metastasis [PDF]
Cell Adhesion & Migration, 2013 Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Shuvojit Moulik +3 more
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The biomechanical integrin [PDF]
Journal of Biomechanics, 2010 The integrin lies at the center of our efforts to understand mechanotransduction in the human body. Over the past two decades, a wealth of information has yielded important insights into integrin structure and functioning in biochemical pathways; however, relatively little emphasis has been placed on mechanics.
Muhammad H. Zaman, Erin L. Baker
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The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins
Frontiers in Neuroscience, 2019 Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the ...
Danielle N. Edwards +3 more
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Nature Communications, 2023 To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix (ECM) proteins is poorly understood.
Maximilian Huber +4 more
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
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