Results 31 to 40 of about 210,881 (328)
Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes [PDF]
Nanoscale, 2020, 12, 19918, 2020 Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ...
arxiv +1 more source
The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering [PDF]
, 2014 Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a ...
Bouaouina, Mohamed +7 more
core +4 more sources
Synergistic growth factor microenvironments [PDF]
, 2016 Growth factors (GF) are remarkably powerful signalling molecules that orchestrate developmental biology. GFs are currently used in medjcal applications with limited success but it is clear that if their potential can be harnessed for biomedicine then ...
Dalby, Matthew J. +1 more
core +1 more source
Integrin activation states and eosinophil recruitment in asthma
Frontiers in Pharmacology, 2013 Eosinophil arrest and recruitment to the airway in asthma are mediated, at least in part, by integrins. Eosinophils express α4β1, α6β1, αLβ2, αMβ2, αXβ2, αDβ2, and α4β7 integrins, which interact with counter-receptors on other cells or ligands in the ...
Mats W Johansson, Deane F Mosher
doaj +1 more source
Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury [PDF]
, 2020 Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and ...
Basta, Jeannine +5 more
core +1 more source
Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Cell Communication and Signaling, 2023 Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain.
Siyi Li +4 more
doaj +1 more source
Integral Roles for Integrins in γδ T Cell Function
Frontiers in Immunology, 2018 Integrins are adhesion receptors on the cell surface that enable cells to respond to their environment. Most integrins are heterodimers, comprising α and β type I transmembrane glycoprotein chains with large extracellular domains and short cytoplasmic ...
Gabrielle M. Siegers
doaj +1 more source
Cells, 2022 Smooth muscle cells (SMCs), present in the media layer of blood vessels, are crucial in maintaining vascular homeostasis. Upon vascular injury, SMCs show a high degree of plasticity, undergo a change from a “contractile” to a “synthetic” phenotype, and ...
Manish Jain, Anil K. Chauhan
doaj +1 more source
Paramagnetic response of muscle-type systems [PDF]
Phys. Rev. E 93, 062407 (2016), 2015 We provide a prototypical description of mechanically-induced collective conformational change (folding), relevant in a variety of biological contexts from muscle contraction to hair cell gating and integrin binding. Our study is inspired by the seminal Huxley-Simmons (HS) model which we reinterpret from the perspective of stochastic dynamics involving
arxiv +2 more sources
Molecular Therapy: Oncolytics, 2022 High-grade gliomas (HGGs) are lethal central nervous system tumors that spread quickly through the brain, making treatment challenging. Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) interactions, cellular adhesion ...
Kimberly Ann Rivera-Caraballo +4 more
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