Results 101 to 110 of about 17,756,051 (243)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Discover Applied SciencesTo address the challenge of trajectory prediction for highly maneuverable aerial targets, this paper introduces the novel Intention-guided Interactive Multiple Model (IGIMM) method. Following a “recognize-then-predict” approach, this model first performs
Panghe Qiu +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A model for high-multiplicity πp interactions
Nuclear Physics B, 1969 Abstract The transition matrix element S for high multiplicity reactions πp → p+ (N − 1)π is assumed to depend only on the four-momentum transfer, t, from the initial to the secondary nucleon. A method of deriving the so-called F(t) function giving the empirical form of the averaged t-dependence of the matrix element for many-body processes is ...
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Robust Drone Tracking System Using Distributed FMCW Radars and State-Aware Adaptive IMM-EKF
IEEE AccessSmall multi-rotor drones have become a significant security concern, necessitating robust and continuous tracking systems. Conventional tracking filters, primarily designed for fixed-wing aircraft, rely on standard kinematic models that are inadequate ...
Huijea Park +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Two-Dimensional Ising Model with Competing Interactions as a Model for Interacting pi-Rings [PDF]
, 2009 We investigate the Ising model on a square lattice with antiferromagnetic exchange between nearest and next-nearest neighbors and show that at low temperatures stripe-like and droplet-like superstructures appear.
O'Hare, Anthony +2 more
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