Results 81 to 90 of about 17,756,051 (243)

SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts. [PDF]

, 2018
BackgroundThere is a pressing need for robust longitudinal cohort studies in the modern treatment era of multiple sclerosis.ObjectiveBuild a multiple sclerosis (MS) cohort repository to capture the variability of disability accumulation, as well as ...
Uitdehaag, Bernard M.J., KAPPOS, L. D., Cree, Bruce Ac, Hauser, Stephen L., Chitnis, Tanuja, Cree, Bruce Anthony C.C., Montalban, Xavier, Bove, Riley, Weiner, Howard L, Hauser, Stephen L, Kappos, Ludwig, Khoury, Samia J., Khoury, Samia J, Weiner, Howard L., Tintoré, Mar, SUMMIT Consortium, Naegelin, Yvonne, Uitdehaag, Bernard Mj, Bové, Riley Marie   +18 more
core   +1 more source

Enhancing Object Estimation by Camera-LiDAR Sensor Fusion Using IMM-KF With Error Characteristics in Autonomous Robot Systems

IEEE Access
In autonomous robot systems, accurate object recognition and estimation are crucial for ensuring reliable performance, and sensor fusion techniques that combine complementary sensors have proven to be effective in achieving this.
Sun Ho Lee, Woo Young Choi
doaj   +1 more source

Multi-Sensor Fusion with Interacting Multiple Model Filter for Improved Aircraft Position Accuracy

Sensors, 2013
The International Civil Aviation Organization (ICAO) has decided to adopt Communications, Navigation, and Surveillance/Air Traffic Management (CNS/ATM) as the 21st century standard for navigation.
Changho Lee, Taehwan Cho, Sangbang Choi
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Dual Forgetting Factor-Based Adaptive IMM-UKF Algorithm for Vehicle Tracking

IEEE Access
In response to the limitations of the traditional Interacting Multiple Model Unscented Kalman Filter (IMM-UKF) in high-noise environments—particularly its insufficient tracking accuracy and poor adaptability of the noise covariance matrices—
Jiaye Xie
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Advanced Real-Time State of Charge Estimation in a Hybrid Aircraft Using Dual Filter Interacting Multiple Model

IEEE Access
Hybrid and electric aircraft offer a viable solution to reducing the environmental impact of conventional aviation, which aligns with the industry’s intention to reduce its carbon footprint while maintaining safety and operational standards ...
Reza Hosseininejad, Steven Recoskie, Patrick Zdunich, Peyman Setoodeh, Saeid Habibi   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An Online Detection and Rejection Method for Consecutive Outliers in Underwater Long-Baseline Positioning Based on Kinematic Constraints

Sensors
To address the issue of persistent high-magnitude outlier interference affecting long-baseline (LBL) positioning systems in complex marine environments, this paper proposes a kinematic constraint-based Robust Interacting Multiple Model Kalman Filter ...
Le Wang, Jun Su, Runze Mao, Sha Wang
doaj   +1 more source