Results 41 to 50 of about 644,901 (250)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Instructed L2 Interactional Competence in the First Year

open access: yes, 2019
This chapter illustrates the outcomes of the first two semesters of university language instruction targeting the development of interactional competence (IC) in Chinese as a Foreign Language, with a specific focus on active listenership and topic ...
Kunitz, Silvia,, Yeh, Meng
core   +1 more source

A Series of Conversation Analysis Based Pedagogical Activities for Increasing Interactional Awareness

open access: yesAraştırma Temelli Etkinlik Dergisi, 2019
This article presents a series of activities that are informed by research on conversation analysis and used for increasing the EFL [English as a Foreign Language] learners’ awareness of interactional mechanisms of English language.
Ufuk Balaman, Nilüfer Can Daşkın
doaj   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Interactional competence in GFL/GSL: Introduction to the third issue

open access: yes, 2023
Die Einführung in die dritte Ausgabe der „Zeitschrift für Interaktionsforschung in DaFZ“ nimmt die  Komplexität des Konstrukts der Interaktionskompetenz zum Ausgangspunkt und unterstreicht die Relevanz interdisziplinärer Perspektiven in der Erforschung ...
Aguado, Karin, Thaller, Florian
core   +1 more source

Embodiment, Semantics and Social Action: The Case of Object-Transfer in L2 Classroom Interaction

open access: yesFrontiers in Communication, 2021
Using conversation analysis and usage-based linguistics, I focus on a beginning L2 user in an ESL classroom and trace his use of a “family of expressions” which, from the perspective of linguistic theory, are instantiations of either the ditransitive ...
S. W. Eskildsen
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Development of Interactional Competence in a Virtual Exchange Setting: Focus on Diversification of Participatory Actions

open access: yesInternational Journal of Qualitative Methods
Virtual exchange (VE) projects create environments providing VE participants with L2 development opportunities. This study examines the affordances of VEs with a particular emphasis on how participants find opportunities for developing their ...
Semih Ekin
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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