Results 41 to 50 of about 5,935 (298)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Teachers’ Limited Wait-Time Practice and Learners’ Participation opportunities in EFL Classroom Interaction [PDF]
Journal of English Language Teaching and Learning, 2013 Pairing theory with methodology, this study demonstrates how EFL teachers’ limited wait-time practice structures in and affects the structuring of the unfolding classroom discourse with reference to learners’ participation opportunities.
Bager Yaqubi, Mostafa Pourhaji Rokni
doaj
Embodiment, Semantics and Social Action: The Case of Object-Transfer in L2 Classroom Interaction
Frontiers in Communication, 2021 Using conversation analysis and usage-based linguistics, I focus on a beginning L2 user in an ESL classroom and trace his use of a “family of expressions” which, from the perspective of linguistic theory, are instantiations of either the ditransitive ...
S. W. Eskildsen
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How do learners perceive interactional feedback? [PDF]
, 2000 Theoretical claims about the benefits of conversational interaction have been made by Gass (1997), Long (1996), Pica (1994), and others. The Interaction Hypothesis suggests that negotiated interaction can facilitate SLA and that one reason for this could
Gass, Susan M. +2 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Romanica CracoviensiaThis article discusses the development of communicative language competence among Polish-speaking students learning French remotely during the Covid-19 pandemic. The first part outlines the complexity
Wioletta A. Piegzik, Ewelina Mitera
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Instructed L2 Interactional Competence in the First Year
, 2019 This chapter illustrates the outcomes of the first two semesters of university language instruction targeting the development of interactional competence (IC) in Chinese as a Foreign Language, with a specific focus on active listenership and topic ...
Kunitz, Silvia,, Yeh, Meng
core +1 more source
Araştırma Temelli Etkinlik Dergisi, 2019 This article presents a series of activities that are informed by research on conversation analysis and used for increasing the EFL [English as a Foreign Language] learners’ awareness of interactional mechanisms of English language.
Ufuk Balaman, Nilüfer Can Daşkın
doaj +4 more sources
Cross-Cultural Pragmatics of Interactional Competence
Baltic Journal of English Language, Literature and Culture, 2011 Interactional competence involves knowledge of the relation between language forms and the social contexts in which they are applied. The paper aims at focusing on the concept of interactional competence within the framework of cross-cultural pragmatics.
Gunta Roziņa
doaj