Results 31 to 40 of about 644,901 (250)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing interactional competence

, 2022
The development of speaking competence is widely regarded as a central aspect of second language (L2) learning. It may be questioned, however, if the currently predominant ways of conceptualising the term fully satisfy the complexity of the construct ...
Reinhardt, Susanne (Dr.)
core   +1 more source

Strategic interactional sequencing in Sanskrit epic dialogue as a model for communicative language training in ELE

Frontiers in Education
Recent work in English Language Teaching emphasises communicative competence beyond grammatical accuracy, yet existing pedagogical models often under-theorise how communication emerges through discourse. This study investigates how interactional patterns
Jagdeep Panchal, Ganesh Chilkhe, Vikhyath Shetty   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

La construction de la compétence à communiquer langagièrement en français langue étrangère à l’époque de la pandémie du Covid-19 : entre succès et échecs

Romanica Cracoviensia
This article discusses the development of communicative language competence among Polish-speaking students learning French remotely during the Covid-19 pandemic. The first part outlines the complexity
Wioletta A. Piegzik, Ewelina Mitera
doaj   +1 more source

Teachers’ Limited Wait-Time Practice and Learners’ Participation opportunities in EFL Classroom Interaction [PDF]

Journal of English Language Teaching and Learning, 2013
Pairing theory with methodology, this study demonstrates how EFL teachers’ limited wait-time practice structures in and affects the structuring of the unfolding classroom discourse with reference to learners’ participation opportunities.
Bager Yaqubi, Mostafa Pourhaji Rokni
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cross-Cultural Pragmatics of Interactional Competence

Baltic Journal of English Language, Literature and Culture, 2011
Interactional competence involves knowledge of the relation between language forms and the social contexts in which they are applied. The paper aims at focusing on the concept of interactional competence within the framework of cross-cultural pragmatics.
Gunta Roziņa
doaj