Results 71 to 80 of about 98,491 (346)

Progress in interferon-gamma release assay development and applications: an unfolding story of translational research.

Annals of Translational Medicine, 2019
The introduction of blood-based tests for M. tuberculosis ( Mtb ) infection approximately 15 years ago was a turning point for diagnosis of latent tuberculosis (TB).
A. Lalvani, H. Whitworth
semanticscholar   +1 more source

Tuberculin Test versus Interferon Gamma Release Assay in Pregnant Women with Household Contacts of Tuberculosis Patients

The International Journal of Mycobacteriology, 2022
Background: Pregnant women who live in tuberculosis (TB)-affected households are more likely to develop latent TB infection (LTBI), which often escapes treatment. This study aims to determine if Interferon-gamma release (IGRA) is reliable in screening for LTBI in pregnant women, compare to the tuberculin skin test (TST).
Maisuri Tadjuddin Chalid, Dian Puspawaty, Andi Mardiah Tahir, Hidayah Najdah, Muhammad Nasrum Massi   +4 more
openaire   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Comparison of Two Commercially Available Interferon-γ Release Assays for T-Cell-Mediated Immunity and Evaluation of Humoral Immunity against SARS-CoV-2 in Healthcare Workers

Diagnostics, 2023
Cellular immunity against SARS-CoV-2 is an important component of the immune response to the virus. At present, two such tests based on interferon-gamma release (interferon-γ release assays, IGRAs) are available—Quan-T-Cell SARS-CoV-2 by EUROIMMUN and T ...
Alexandra Lochmanová, Jan Martinek, Hana Tomášková, Hana Zelená, Kersten Dieckmann, Evelin Grage-Griebenow, Eduard Ježo, Jaroslav Janošek   +7 more
doaj   +1 more source

Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis

PLoS ONE, 2017
Background Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the ...
T. Doan, D. Eisen, M. Rose, A. Slack, G. Stearnes, E. McBryde   +5 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Uloga testova otpuštanja interferona gama u nadzoru nad tuberkulozom [PDF]

, 2012
Tuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation.
A Detjen, A Dyrhol-Riise, A Jurčev-Savičević, A Lalvani, A Mandalakas, A Naseer, A Nienhaus, A Pooran, A Seidler, A Veerapathran, A Zwerling, Anamarija Jurčev-Savičević, B Bergamini, B Linas, C Baker, C Denkinger, C Lange, C Lange, D Dosanjh, D Goletti, D Menzies, D Tripodi, E Bruzzese, E Kim, F Piana, F Ringshausen, G Mazurek, H Igari, H Rieder, I Pavić, Ivan Gudelj, J Broekmans, J Choi, J Lighter, J Torres Costa, J Torres Costa, K Ewer, K Higuchi, Kornelija Miše, M Madariaga, M Pai, M Pai, M Pai, M Pai, M Pai, M Pai, M Pai, M Sester, N Harada, R Diel, R Diel, R Diel, R Diel, R Diel, R Diel, R Van Zyl-Smit, S Lee, S Perry, T Connell, T. Mori, U Mack, Vera Katalinić-Janković, Y Kobashi   +62 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Characteristics of indeterminate QuantiFERON-TB Gold PLUS results in pediatric lupus nephritis at Beijing Children’s Hospital, 2023–2024

BMC Nephrology
Objectives Tuberculosis screening in pediatric lupus nephritis (LN) patients presents unique diagnostic challenges. This study aimed to analyze the frequency of indeterminate QuantiFERON-TB Gold Plus (QFT-Plus) results among children with LN and the ...
Yue Xi, Huiwen Zheng, Yonghong Wang, Yajie Guo, Jing Xiao, Feina Li, Hui Qi, Weiwei Jiao, Nan Zhou, Zhi Chen, Lin Sun   +10 more
doaj   +1 more source

Interferon-gamma release assays and tuberculin skin testing for diagnosing latent Mycobacterium tuberculosis infection in at-risk groups in Poland

International Journal of Mycobacteriology, 2016
Objective/Background: The diagnostics of latent tuberculosis infection in Poland using the tuberculin skin test is challenging due to the obligatory Bacillus Calmette–Guérin vaccinations.
Katarzyna Kruczak, Lucyna Mastalerz, Krzysztof Sładek   +2 more
doaj   +1 more source