The type I interferon response in COVID-19: implications for treatment
Nature reviews. Immunology, 2020 Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection.
Jeong Seok Lee, E. Shin
semanticscholar +1 more source
Modelling the cost effectiveness of interferon beta and glatiramer acetate in the management of multiple sclerosis [PDF]
, 2003 OBJECTIVE: To evaluate the cost effectiveness of four disease modifying treatments (interferon betas and glatiramer acetate) for relapsing remitting and secondary progressive multiple sclerosis in the United Kingdom. DESIGN: Modelling cost effectiveness.
Abrams, K. +6 more
core +2 more sources
The IFITMs Inhibit Zika Virus Replication
Cell Reports, 2016 Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here,
George Savidis +6 more
doaj +1 more source
Double-edged effects of interferons on the regulation of cancer-immunity cycle
OncoImmunology, 2021 Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types.
Xiao Zhang +7 more
doaj +1 more source
Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis
Frontiers in Immunology, 2023 Early detection of infection is a central and critical component of our innate immune system. Mammalian cells have developed specialized receptors that detect RNA with unusual structures or of foreign origin – a hallmark of many virus infections ...
Sarah Straub +3 more
doaj +1 more source
Interferon-α2b Treatment for COVID-19
Frontiers in Immunology, 2020 The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. In
Qiong Zhou +9 more
semanticscholar +1 more source
Porcine innate and adaptative immune responses to influenza and coronavirus infections [PDF]
, 2006 Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans.
Asselin-Paturel +35 more
core +2 more sources
Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]
, 2008 The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T. +6 more
core +2 more sources
Role of Type I and II Interferons in Colorectal Cancer and Melanoma
Frontiers in Immunology, 2017 Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development.
Simone Di Franco +4 more
doaj +1 more source
Evaluation of prognostic value of cell adhesion molecules in chronic hepatitis C therapy
Journal of Venomous Animals and Toxins including Tropical Diseases, 2010 The most reliable determination of severity and prognosis in chronic viral hepatitis is the histological staging of the disease, which comprises an invasive procedure and is often not well accepted by patients.
N Abdallah +3 more
doaj +1 more source