Results 41 to 50 of about 574,262 (313)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Double-edged effects of interferons on the regulation of cancer-immunity cycle [PDF]

, 2021
Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Zheng‐Xiang Li   +7 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Comparative Transcriptomics Reveals Novel and Differential Circular RNA Responses Underlying Interferon-Mediated Antiviral Regulation in Porcine Alveolar Macrophages

Viruses
Porcine Reproductive and Respiratory Syndrome (PRRS) causes significant economic losses in the swine industry. Circular RNAs (circRNAs), a class of stable non-coding RNAs, are increasingly recognized as regulators in immune responses and host–virus ...
Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang   +3 more
doaj   +1 more source

The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response

Frontiers in Cell and Developmental Biology, 2020
It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response.
Mariska van Huizen, Marjolein Kikkert
doaj   +1 more source

Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus [PDF]

, 2021
Rui Zhang, Jun Tang
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response

Journal of Virology
Long noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here, we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infections by ...
Kristen John, Ian Huntress, Ethan Smith, Hsuan Chou, Tammy S. Tollison, Sergio Covarrubias, Elisa Crisci, Susan Carpenter, Xinxia Peng   +8 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions

Journal of Virology
The cell that a virus replicates in, that is, the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced.
Gary Dunn, Luke F. Domanico, Matthew P. Taylor   +2 more
doaj   +1 more source