Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells
Frontiers in Immunology, 2020 Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations.
Michael Sörensen +15 more
doaj +1 more source
Interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity [PDF]
arXiv, 2022 Enveloped viral infections require fusion with cellular membranes for viral genome entry, occurring only following interaction of viral and cellular membranes allowing fusion pore formation, by which the virus accesses the cytoplasm. Here, we focus on interferon-induced transmembrane protein 3 (IFITM3) and its antiviral activity. IFITM3 is predicted to
arxiv
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
Frontiers in Immunology, 2018 Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases ...
F. Castro +4 more
semanticscholar +1 more source
Stratification of Systemic Lupus Erythematosus Patients Using Gene Expression Data to Reveal Expression of Distinct Immune Pathways [PDF]
, 2020 Systemic lupus erythematosus (SLE) is the tenth leading cause of death in females 15-24 years old in the US. The diversity of symptoms and immune pathways expressed in SLE patients causes difficulties in treating SLE as well as in new clinical trials.
arxiv +1 more source
Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice [PDF]
Терапевтический архив, 2016 Objective: to assess the efficacy and safety of the medication Grippferon with loratadine for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemics.
D I Trukhan, A L Mazurov, L A Rechapova
doaj +1 more source
Interferons and Interferon Regulatory Factors in Malaria [PDF]
Mediators of Inflammation, 2014 Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies.
Sin Yee Gun +3 more
openaire +5 more sources
The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response
Frontiers in Cell and Developmental Biology, 2020 It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response.
Mariska van Huizen, Marjolein Kikkert
doaj +1 more source
Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection
Frontiers in Immunology, 2016 The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using
Takahisa Kouwaki +11 more
doaj +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
The Role of Structure in the Biology of Interferon Signaling
Frontiers in Immunology, 2020 Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three ...
Mark R. Walter
doaj +1 more source