Results 241 to 250 of about 118,218,999 (286)

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Interferon-gamma regulates the progression of neuroblastoma cells through interferon-regulatory factor-1

BIOCELL
JING WANG, JUNFENG XU, YINGRAN YANG, YOUZHENG QIU, SHANSHAN ZHANG, NING WANG   +5 more
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

Science, 1993
Interferon regulatory factor-1 (IRF-1), a transcriptional activator, and IRF-2, its antagonistic repressor, have been identified as regulators of type I interferon and interferon-inducible genes. The IRF-1 gene is itself interferon-inducible and hence may be one of the target genes critical for interferon action ...
Hisashi Harada, Nobuyuki Tanaka, Motoo Kitagawa   +2 more
exaly   +3 more sources

Interferon Regulatory Factor-1 Expression in Human Uterine Endometrial Carcinoma

Gynecologic Oncology, 2003
The objective was to investigate the expression of interferon regulatory factors 1 (IRF-1) in human uterine endometrial carcinoma.Formalin-fixed, paraffin-embedded, archival tissue specimens from 76 human endometrial carcinomas and stained with polyclonal anti-IRF-1 antibody, using immunohistochemistry, localization, and immunostaining, were evaluated ...
Haruo Kuroboshi, Shinji Fushiki, Kotaro Kitaya   +2 more
exaly   +3 more sources

Interferon Regulatory Factor 9 Structure and Regulation [PDF]

Frontiers in Immunology, 2018
Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has
Thean-Hock Tang, Siew Kit Ng
exaly   +2 more sources

Roles of Interferon-Regulatory Factors in T-Helper-Cell Differentiation

Nature Reviews Immunology, 2005
Members of the interferon-regulatory factor family of transcription factors have long been known to be intracellular mediators of the effects of interferons. In recent years, interferon-regulatory factors have also been shown to have an essential role in
Tak W Mak, Michael Lohoff
exaly   +2 more sources

Interferon regulatory factor 1 promoter polymorphism and response to type 1 interferon

Journal of Cellular Biochemistry, 2001
The clinical success of interferon-treatment has been found to vary in different individuals. To explain this, we hypothesized that responses to type 1 interferons could be partly determined by interferon regulatory factor-1 gene transcription, because the latter is an important transcription factor in the interferon system.
H, Saito, S, Tada, H, Ebinuma, K, Wakabayashi, T, Takagi, Y, Saito, N, Nakamoto, S, Kurita, H, Ishii   +8 more
openaire   +2 more sources

HIV and Interferon Regulatory Factor 1: A Story of Manipulation and Control

AIDS Research and Human Retroviruses, 2013
Members of the interferon regulatory factor (IRF) family control the expression of numerous proteins, many of which are central to regulating host immune responses. IRF1 is one of the central mediators of the innate and adaptive immune responses required for antigen processing and presentation, Th1/Th2 differentiation, and natural killer (NK) cell and ...
Sivro, A, Su, RC, Plummer, FA, Ball, TB.
openaire   +2 more sources