Results 251 to 260 of about 118,218,999 (286)

Interferon regulatory factor 1 is induced by interferon-γ equally in neurons and glial cells

Journal of Neuroimmunology, 1997
Class I MHC protein is induced in glia but not mature neurons by IFN-gamma. We have compared IFN-gamma signal transduction in these populations. There were identical levels of STAT1 homodimers and IRF-1 by gel-shift and IRF-1 mRNA was induced equally.
Thomas, HE, Dutton, R, Bartlett, PF, Kay, TWH   +3 more
openaire   +5 more sources

Deletion of interferon-regulatory factor-1 results in cognitive impairment

Hypertension Research, 2018
Interferon-regulatory factor (IRF)-1-dependent genes in neurons play a role in ischemic neuronal death; however, the roles of IRF-1 in dementia are not well investigated. Therefore, we assessed the effect of IRF-1 on cognitive function using a vascular cognitive impairment mouse model created by chronic cerebral hypoperfusion. Male 10-week-old C57BL/6 (
Masaki, Mogi, Jun, Iwanami, Xiao-Li, Wang, Kana, Tsukuda, Harumi, Kan-No, Hui-Yu, Bai, Bao-Shuai, Shan, Akinori, Higaki, Li-Juan, Min, Masatsugu, Horiuchi   +9 more
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Stimulation of interferon regulatory factor-1 by prolactin

Lupus, 2001
Prolactin (PRL), a pituitary peptide hormone, is known to regulate diverse cellular functions including proliferation, differentiation, angiogenesis and protection against apoptosis and inflammation. To understand the mechanism of PRL signaling in T cells, we have cloned both PRL and its receptor (PRL-R), one potent mediator of PRL signaling, Stat5b ...
openaire   +2 more sources

Human Interferon Regulatory Factor 1: Intron-Exon Organization

DNA and Cell Biology, 1992
Interferon (IFN) regulatory factor 1 (IRF-1) is a transcriptional regulatory protein that mediates the transcriptional activation of the IFN-alpha and IFN-beta genes by viruses and IFNs. To characterize the mechanisms that govern the level of IRF-1 in cells, we isolated the IRF-1 gene and characterized the structure of its intronic and exonic domains ...
Y, Cha, S H, Sims, M F, Romine, M, Kaufmann, A B, Deisseroth   +4 more
openaire   +2 more sources

Functional dissection of the transactivation domain of interferon regulatory factor-1

Biochemical and Biophysical Research Communications, 2003
Interferon regulatory factor-1 (IRF-1), a putative tumor suppressor protein, is a transcriptional mediator of interferon-responsive signaling pathways that are involved in antiviral defense, apoptosis, immune response, and cell growth regulation. To delineate the IRF-1 domain responsible for transactivation, we performed a detailed deletion analysis of
Eun-Joo, Kim, Chong-Ho, Park, Jong-Sup, Park, Soo-Jong, Um   +3 more
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NFκB activation is required for interferon regulatory factor‐1‐mediated interferon β induction

European Journal of Biochemistry, 1999
The interferon regulatory factor 1 (IRF‐1) acts as a transcriptional inducer of the interferon β (IFN‐β) gene and interferon‐stimulated genes. Here we report that IRF‐1‐mediated IFN‐β induction depends on NFκB activity. IRF‐1 by itself initiates NFκB activation by inducing a reduction in cellular MAD3/IκBα, an inhibitor of NFκB.
Kirchhoff, S, Wilhelm, D, Angel, P, Hauser, H   +3 more
openaire   +5 more sources

Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation

Biochemical Journal, 2001
Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act as their effectors. It is increasingly evident that the interferon regulatory factor-1 (IRF-1) transcription factor can selectively regulate different sets of genes depending on the cell type and/or the nature of cellular stimuli ...
E M, Coccia, E, Stellacci, M, Valtieri, B, Masella, T, Feccia, G, Marziali, J, Hiscott, U, Testa, C, Peschle, A, Battistini   +9 more
openaire   +2 more sources

Interferon Regulatory Factor-1 and -2 Expression in Human Melanoma Specimens

Annals of Surgical Oncology, 1999
Interferon regulatory factor (IRF)-1 and IRF-2 are nuclear transcription factors that respond to interferon-gamma. IRF-1 acts as the effector arm of the interferon-gamma response in tumor cells, whereas IRF-2 binds to the same DNA consensus sequence and opposes IRF-1 activity. This effect is intact in human and murine tumor models, including melanomas;
J K, Lowney, L D, Boucher, P E, Swanson, G M, Doherty   +3 more
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Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene

Molecular and Cellular Endocrinology, 2001
Transcription of the interferon regulatory factor-1 gene (IRF-1) is induced in a biphasic manner (G1 and G1/S phase) in Nb2 T cells in response to prolactin (PRL) stimulation. Signal transducer and activator of transcription 1 (Stat1) is required for PRL activation of the IRF-1 promoter. Mutation of a -200 bp Sp1 site in the IRF-1 promoter results in a
M, Book McAlexander, L Y, Yu-Lee
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The regulation role of interferon regulatory factor-1 gene and clinical relevance

Human Immunology, 2014
IRF-1, a kind of transcription factors, is expressed constitutively in all cells types except early embryonal cells. By virtue of its interaction with specific DNA sequence, IRF-1 regulates the transcription of a set of target genes which play essential roles in various physiological and pathological processes, including viral infection, tumor immune ...
Lei, Dou, Hui-Fang, Liang, David A, Geller, Yi-Fa, Chen, Xiao-Ping, Chen   +4 more
openaire   +2 more sources