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Associations between interferon regulatory factor–1 polymorphisms and Behçet’s disease
Human Immunology, 2007Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates the functions of type I and II interferons and plays a role in host protection. Behçet's disease (BD) is an idiopathic systemic vasculitis that is often complicated with thrombotic features, and infectious agents have long been postulated to be a disease-triggering factor ...
Yun Jong, Lee +9 more
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Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination
Reviews in the Neurosciences, 2012Oligodendrocyte injury and inflammatory demyelination are key pathological abnormalities of multiple sclerosis (MS), and its animal model, i.e., the experimental autoimmune encephalomyelitis (EAE). Traditionally, they are viewed as destructive processes secondary to a dysregulated autoimmune reaction.
Eileah, Loda, Roumen, Balabanov
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Interferon regulatory factor‐1 mediates interferon‐γ‐induced apoptosis in ovarian carcinoma cells
Journal of Cellular Biochemistry, 2002AbstractInterferon‐γ (IFN‐γ), as one of interferon family that regulates antiviral, antiproliferative, and immunomodulatory responses, has been implicated for the growth regulation of ovarian cancer cells. However, the molecular mechanisms are not yet fully defined. To analyze detailed mechanisms, the ovarian cancer cell lines (2774, PA‐1, OVCAR‐3, and
Eun-Joo, Kim +4 more
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Cytokine induction of interferon regulatory factor-1 in hepatocytes.
Surgery, 1993Interferon regulatory factor-1 (IRF-1) is a transcriptional factor originally cloned from fibroblasts that activates interferons and certain interferon-responsive genes. Because IRF-1 is an "early-immediate" nuclear protein, it can function acutely after trauma or septic stimuli. We have identified IRF-1 expression in hepatocytes in vivo in sepsis. The
D A, Geller +9 more
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Interferon regulatory factor-1 myelodysplasia and leukemia
Leukemia Research, 2006Dan A, Liebermann, Barbara, Hoffman
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The Role of Interferon in Cancer Therapy: A Current Perspective
Ca-A Cancer Journal for Clinicians, 1988David S Goldstein +2 more
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Classics in Oncology: Virus Interference: I. The Interferon
Ca-A Cancer Journal for Clinicians, 1988Alick Isaacs, J Lindenmann, A Isaacs
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