Results 201 to 210 of about 22,608,904 (223)

Fucoxanthin Attenuates Inflammation via Interferon Regulatory Factor 3 (IRF3) to Improve Sepsis

Journal of Agricultural and Food Chemistry, 2023
Suppression of excessive inflammatory responses improves the survival of patients with sepsis. We previously illustrated the anti-inflammatory effects of fucoxanthin (FX), a natural carotenoid isolated from brown algae; nevertheless, the underlying mechanism remains unknown.
Jingqian Su, Biyun Guan, Kunsen Chen, Zhihua Feng, Kai Guo, Xue Wang, Jianbin Xiao, Siyuan Chen, Wenzhi Chen, Long Chen, Qi Chen   +10 more
openaire   +3 more sources

Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3–13.4 by an intragenic polymorphic marker

Annals of Human Genetics, 1998
We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene.
Kevin Gregory-Evans
exaly   +12 more sources

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Stimulator of interferon genes/Interferon regulatory factor 3 (STING-IRF3) and inflammasome-activation mediated pyroptosis biomarkers: a network of integrated pathways in diabetic nephropathy

Journal of Diabetes & Metabolic Disorders, 2023
Diabetic Nephropathy (DN) is serious diabetic complication affecting the structure and function of the kidney. This study assessed the stimulator of interferon genes/ Interferon regulatory factor 3 (STING/IRF3) signaling pathway roles and inflammasome-activation mediated pyroptosis, being imperative pathways of inordinate importance in disease ...
Omnia Safwat El-Deeb, Yasser Mostafa Hafez, Amira Kamel Eltokhy, Marwa Mahmoud Awad, Rehab Ahmed Ahmed El-shaer, Muhammad Tarek Abdel Ghafar, Marwa Mohamed Atef   +6 more
openaire   +3 more sources

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

2023
Abstract Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1 (AIG1) in adipocytes ...
Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel B. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen   +14 more
openaire   +1 more source

Activation of Interferon Regulatory Factor 3 (IRF3) is Required in Both T cells and APCs for Optimal Expression of IFN-γ, IL-17, and Granzyme B during T cell responses.

The Journal of Immunology, 2016
Abstract Recently we saw a link between activation of Interferon Regulatory Factor (IRF)-3 and expression of IFN-γ, as well as Granzyme B (GrB) from T cells during viral infections in C57Bl/6 (B6) and IRF3KO mice. To investigate this further, we stimulated splenic mononuclear cells (SMC) from B6 and IRF3KO mice in vitro with anti-CD3 ...
Thomas M Petro, Zachary Guinn, Anna Lampe   +2 more
openaire   +1 more source

Molecular Characterization and Expression Analysis of the Interferon Regulatory Factor 3 (IRF3) Gene from Red sea Bream Pagrus major

JOURNAL OF FISHRIES AND MARINE SCIENCES EDUCATION, 2020
Kyung Ho KIM, Dong-Hee CHO, Min-Soo JOO, Kwang-Min CHOI, Chan-Il PARK, Mu-Chan KIM   +5 more
openaire   +1 more source

Fucoxanthin Attenuates Inflammation via Interferon Regulatory Factor 3 (IRF3) to Improve Sepsis

Journal of Agricultural and Food Chemistry, 2023
Jingqian Su
exaly  

NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production

Biochemical and Biophysical Research Communications, 2022
Wei Chen, Yi-Ting CAI
exaly  

Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis

Cell Reports, 2022
Changjiang Weng, Kunli Zhang, Ye guangqiang   +2 more
exaly