Results 51 to 60 of about 1,888,881 (401)
Type I interferon in rheumatic diseases [PDF]
Nature Reviews Rheumatology, 2018 The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases ...
Theresa L Wampler, Muskardin +1 more
openaire +2 more sources
Archives of Virology, 2004 Summary.Infection by porcine reproductive and respiratory syndrome virus (PRRSV) results in a weak induction of the innate immune response. There are many genes that collectively comprise this response and the extent to which each gene responds to PRRSV ...
Laura C. Miller +4 more
semanticscholar +1 more source
Type I interferon-mediated tumor immunity and its role in immunotherapy
Cellular and Molecular Life Sciences, 2022 Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses in patients with many different types of cancer; however, most patients who receive ICB monotherapy fail to achieve long-term responses, and some tumors become ...
Renren Yu, B. Zhu, Degao Chen
semanticscholar +1 more source
Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, 2018 Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist +2 more
doaj +1 more source
Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]
, 2008 The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T. +6 more
core +2 more sources
Annals of the Rheumatic Diseases, 2013 Objective To establish an easy and practical assay for identifying systemic interferon (IFN) type I bioactivity in patients with primary Sjögren's syndrome (pSS).
N. Maria +9 more
semanticscholar +1 more source
ADAR1 averts fatal type I interferon induction by ZBP1
Nature, 2022 Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis1–3.
Huipeng Jiao +16 more
semanticscholar +1 more source
Veterinary Research, 2011 This study shows that high pathogenic H5N1 influenza virus infection of chicken induced high levels of bioactive interferon type I in the lung (4.3 × 105 U/mg tissue), plasma (1.1 × 105 U/mL), and spleen (9.1 × 105 U/mg tissue).
Hervé R Moulin +6 more
semanticscholar +1 more source
The interferon-inducible antiviral protein Daxx is not essential for interferon-mediated protection against avian sarcoma virus [PDF]
, 2014 BACKGROUND: The antiviral protein Daxx acts as a restriction factor of avian sarcoma virus (ASV; Retroviridae) in mammalian cells by promoting epigenetic silencing of integrated proviral DNA.
Anna Skalka +5 more
core +1 more source
T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?
Arthritis Research & Therapy, 2014 IntroductionA hallmark of systemic autoimmune diseases like systemic lupus erythematosus (SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN type I signature.
Z. Brkić +13 more
semanticscholar +1 more source