Results 1 to 10 of about 418,491 (266)

Evolution of Interferons and Interferon Receptors [PDF]

Frontiers in Immunology, 2017
The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei ...
C. Secombes, J. Zou
semanticscholar   +5 more sources

The use of intranasal interferon for prevention and treatment of acute respiratory infections

Aktualʹnaâ Infektologiâ, 2021
Interferons are cytokines that are produced by immunocompetent cells in response to the invasion of an infectious factor. The most important biological effect of interferons used in clinical practice is their ability to nonspecifically inhibit viral ...
S.О. Kramarov, V.V. Yevtushenko
doaj   +1 more source

The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family. [PDF]

PLoS ONE, 2009
BACKGROUND:Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone.
Brian A Fox, Paul O Sheppard, Patrick J O'Hara   +2 more
doaj   +1 more source

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Science immunology, 2020
Single-cell RNA sequencing of blood immune cells reveals type I interferon–associated hyper-inflammation in severe COVID-19. Cytokine drivers of COVID-19 By carrying out single-cell RNA sequencing analyses on immune cells in the blood, Lee et al.
Jeong Seok Lee, Seongwan Park, H. Jeong, J. Ahn, S. Choi, Hoyoung Lee, B. Choi, S. Nam, Moa Sa, Ji-Soo Kwon, S. Jeong, H. Lee, S. Park, Su‐Hyung Park, J. Choi, Sung‐Han Kim, Inkyung Jung, E. Shin   +17 more
semanticscholar   +1 more source

Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Frontiers in Immunology, 2021
In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by a ...
Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina, Tiago da Silva Medina   +5 more
doaj   +1 more source

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
Jack Major, S. Crotta, Miriam Llorian, T. M. McCabe, H. Gad, S. Priestnall, R. Hartmann, A. Wack   +7 more
semanticscholar   +1 more source

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
A. Broggi, Sreya Ghosh, B. Sposito, R. Spreafico, F. Balzarini, Antonino Lo Cascio, Nicola Clementi, M. De Santis, N. Mancini, F. Granucci, I. Zanoni   +10 more
semanticscholar   +1 more source

Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

Frontiers in Immunology, 2021
In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited.
Miriam Mojzesz, Magdalena Widziolek, Mikolaj Adamek, Urszula Orzechowska, Piotr Podlasz, Tomasz K. Prajsnar, Niedharsan Pooranachandran, Anna Pecio, Anna Michalik, Win Surachetpong, Magdalena Chadzinska, Krzysztof Rakus   +11 more
doaj   +1 more source

Type I and II Interferons in the Anti-Tumor Immune Response

Cancers, 2021
Simple Summary Interferons are cytokines that play key roles in the activation of cellular components of the immune response, such as dendritic cells, macrophages and T cells. Generally, these cytokines promote anti-tumor immune responses, but under some
Sarah E Fenton, Diana Saleiro, L. Platanias   +2 more
semanticscholar   +1 more source

Interferons: Tug of War Between Bacteria and Their Host

Frontiers in Cellular and Infection Microbiology, 2021
Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs).
Noémie Alphonse, Noémie Alphonse, Ruth E. Dickenson, Charlotte Odendall   +3 more
doaj   +1 more source