Results 1 to 10 of about 420,961 (364)
Evolution of Interferons and Interferon Receptors [PDF]
Frontiers in Immunology, 2017 The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
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The use of intranasal interferon for prevention and treatment of acute respiratory infections
Aktualʹnaâ Infektologiâ, 2021 Interferons are cytokines that are produced by immunocompetent cells in response to the invasion of an infectious factor. The most important biological effect of interferons used in clinical practice is their ability to nonspecifically inhibit viral ...
S.О. Kramarov, V.V. Yevtushenko
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The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family. [PDF]
PLoS ONE, 2009 BACKGROUND:Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone.
Brian A Fox +2 more
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Frontiers in Immunology, 2021 In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by a ...
Glauco Akelinghton Freire Vitiello +5 more
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Frontiers in Immunology, 2021 In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited.
Miriam Mojzesz +11 more
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Interferons: Tug of War Between Bacteria and Their Host
Frontiers in Cellular and Infection Microbiology, 2021 Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs).
Noémie Alphonse +3 more
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The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway
Frontiers in Immunology, 2020 Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune response against multiple challenges like viral infections, autoimmune diseases, and cancer. While numerous anti-tumor activities have been described for IFNs,
Laura Martin-Hijano +5 more
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TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice
Cell Reports, 2016 Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection.
Lee Adam Wheeler +11 more
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Mediators of Inflammation, 1994 The in vitro action of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system.
S. B. Cheknev +5 more
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Frontiers in Cellular and Infection Microbiology, 2022 Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez +14 more
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