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The use of intranasal interferon for prevention and treatment of acute respiratory infections
Aktualʹnaâ Infektologiâ, 2021 Interferons are cytokines that are produced by immunocompetent cells in response to the invasion of an infectious factor. The most important biological effect of interferons used in clinical practice is their ability to nonspecifically inhibit viral ...
S.О. Kramarov, V.V. Yevtushenko
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The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family. [PDF]
PLoS ONE, 2009 BACKGROUND:Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone.
Brian A Fox +2 more
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Interferons—Implications in the Immune Response to Respiratory Viruses
Microorganisms, 2023 Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that ...
Harrison C. Bergeron +2 more
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COVID-19 newer and emerging treatment options
Apollo Medicine, 2021 Coronavirus disease-19 is a highly contagious disease caused by severe acute respiratory syndrome coronavirus-2. It has shown a debilitating and catastrophic effect on the world population and is emerging as a challenging global health crisis, resulting ...
Suneetha Narreddy, Sneha Varahala
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Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
eLife, 2020 Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion.
Anusorn Mudla +9 more
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Interferons: Tug of War Between Bacteria and Their Host
Frontiers in Cellular and Infection Microbiology, 2021 Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs).
Noémie Alphonse +3 more
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Frontiers in Immunology, 2021 In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited.
Miriam Mojzesz +11 more
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The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway
Frontiers in Immunology, 2020 Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune response against multiple challenges like viral infections, autoimmune diseases, and cancer. While numerous anti-tumor activities have been described for IFNs,
Laura Martin-Hijano +5 more
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Viruses, 2020 Oropouche orthobunyavirus (OROV) is an emerging arbovirus with a high potential of dissemination in America. Little is known about the role of peripheral blood mononuclear cells (PBMC) response during OROV infection in humans.
Mariene Ribeiro Amorim +18 more
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Pathogens, 2023 To enhance the efficacy of the current Newcastle disease vaccine, we have selected potential adjuvants that target well-characterized pattern recognition receptors: the toll-like receptors (TLRs). Imiquimod is a small-molecule activator of TLR7, which is
Chang-Won Lee +5 more
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