Results 21 to 30 of about 418,590 (365)
Journal of Translational Medicine, 2018 Background Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach.
Daniel S. Green +10 more
doaj +1 more source
The human antigen R as an actionable super-hub within the network of cancer cell persistency and plasticity [PDF]
Translational Oncology, Volume 35, 2023, 101722, ISSN 1936-5233, 2022 In this perspective article, a clinically inspired phenotype-driven experimental approach is put forward to address the challenge of the adaptive response of solid cancers to small-molecule targeted therapies. A list of conditions is derived, including an experimental quantitative assessment of cell plasticity and an information theory-based detection ...
arxiv +1 more source
Frontiers in Immunology, 2021 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host ...
Krishna Latha +2 more
doaj +1 more source
The Dual Nature of Type I and Type II Interferons
Frontiers in Immunology, 2018 Type I and type II interferons (IFN) are central to both combating virus infection and modulating the antiviral immune response. Indeed, an absence of either the receptor for type I IFNs or IFN-y have resulted in increased susceptibility to virus ...
Amanda J. Lee, A. Ashkar
semanticscholar +1 more source
Nature Network Boston, 2016 Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-Is) in astrocytes during experimental CNS autoimmunity and also ...
V. Rothhammer +21 more
semanticscholar +1 more source
Opposing Roles of Type I Interferons in Cancer Immunity.
Annual Review of Pathology, 2020 The immune system is tasked with identifying malignant cells to eliminate or prevent cancer spread. This involves a complex orchestration of many immune cell types that together recognize different aspects of tumor transformation and growth. In response,
Giselle M. Boukhaled +2 more
semanticscholar +1 more source
mBio, 2020 While there is no effective vaccine against Chlamydia trachomatis infection, previous work has demonstrated the importance of C. trachomatis-specific CD4+ T cells (NR1 T cells) in pathogen clearance.
Jennifer D. Helble +3 more
doaj +1 more source
Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains
mBio, 2020 Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus infection.
Rebekah Honce +6 more
doaj +1 more source
Lymphoid Stress Surveillance Response Contributes to Vitiligo Pathogenesis
Frontiers in Immunology, 2018 Vitiligo is a chronic multifactorial depigmentation disorder characterized by the destruction and functional loss of melanocytes. Although a direct cytotoxic T cell attack is thought to be responsible for melanocyte damage, the events leading to the loss
Liisi Raam +16 more
doaj +1 more source
Time and length scales of autocrine signals in three dimensions [PDF]
Biophys J. 2007 Sep 15;93(6):1917-22, 2007 A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived.
arxiv +1 more source