Results 51 to 60 of about 418,590 (365)
mBio, 2019 Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear.
Jordan V. Price +7 more
doaj +1 more source
Immuno, 2022 The pathogenesis of COVID-19 is complicated by immune dysfunction. The impact of immune-based therapy in COVID-19 patients has been well documented, with some notable studies on the use of anti-cytokine medicines.
Deepshikha Yadav +12 more
doaj +1 more source
Prediction uncertainty and optimal experimental design for learning dynamical systems [PDF]
Chaos 26, 063110 (2016), 2015 Dynamical systems are frequently used to model biological systems. When these models are fit to data it is necessary to ascertain the uncertainty in the model fit. Here we present prediction deviation, a new metric of uncertainty that determines the extent to which observed data have constrained the model's predictions.
arxiv +1 more source
IRF3 and Type I Interferons Fuel a Fatal Response to Myocardial Infarction
Nature Network Boston, 2017 Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières syndrome and STING-associated ...
K. King +17 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic
mBio, 2018 A balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense.
Marcin Stawowczyk +5 more
doaj +1 more source
Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
eLife, 2020 Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion.
Anusorn Mudla +9 more
doaj +1 more source
African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
Viruses, 2023 African swine fever (ASF) is a hemorrhagic viral disease of domestic pigs and wild suids (all Sus scrofa) caused by the ASF virus (ASFV). The disease is spreading worldwide without control, threatening pig production due to the absence of licensed ...
Giulia Franzoni +2 more
doaj +1 more source
Regulation of interferon production as a potential strategy for COVID-19 treatment [PDF]
arXiv, 2020 Regulating the upstream of the cytokines production could be a promising strategy to the treatment of COVID-19. We suggest to pay more attention to the dysregulated IFN-I production in COVID-19 and to considerate cGAS, ALK and STING as potential therapeutic targets preventing cytokine storm.
arxiv
Journal of General Virology, 2008 The interferon (IFN) system is an extremely powerful antiviral response that is capable of controlling most, if not all, virus infections in the absence of adaptive immunity.
R. Randall, S. Goodbourn
semanticscholar +1 more source