Results 61 to 70 of about 223,138 (357)

Interferons in the treatment of myeloproliferative neoplasms

Therapeutic Advances in Hematology
Interferons are cytokines with immunomodulatory properties and disease-modifying effects that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years.
Pankit Vachhani, John Mascarenhas, Prithviraj Bose, Gabriela Hobbs, Abdulraheem Yacoub, Jeanne M. Palmer, Aaron T. Gerds, Lucia Masarova, Andrew T. Kuykendall, Raajit K. Rampal, Ruben Mesa, Srdan Verstovsek   +11 more
doaj   +1 more source

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
doaj   +1 more source

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Porcine innate and adaptative immune responses to influenza and coronavirus infections [PDF]

, 2006
Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans.
Asselin-Paturel, Baudoux, BERNARD CHARLEY, Brim, Charley, Charley, Charley, Chen, Chinsangaram, Corthier, Fitzgerald-Bocarsly, Guzylack-Piriou, Heinen, KRISTIEN VAN REETH, La Bonnardière, Laude, Laude, Le Bon, Lim, Liu, Palese, Peiris, Pestka, Riffault, Riffault, Riffault, Rothenfusser, SABINE RIFFAULT, Saif, Siegal, Summerfield, Tu, Tudor, Van Reeth, Van Reeth, van Reeth   +35 more
core   +2 more sources

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide [PDF]

, 2023
Michelle C. Rice, M Imun, SW Jung, CY Park, JS Kim, RW Lai, CR Barr, JM Son, K Tor, E Kim, RJ Lu, Ira L. Cohen, BA Benayoun, Changhan Lee   +13 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Multiple sclerosis: evidence and controversies [PDF]

Revista Ciencias de la Salud, 2006
Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with
Ángela María Gutiérrez-Álvarez
doaj  

PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA

Детские инфекции (Москва), 2018
Objective: study of immune status indices in newborns  in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns  with non-specific clinical symptoms were studied.
L. V. Kravchenko
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source