Results 11 to 20 of about 633,289 (295)

Biology of interleukin-10 [PDF]

Cytokine & Growth Factor Reviews, 2010
Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes/macrophages and T cell subsets including Tr1, Treg, and Th1 cells. IL-10 acts through a transmembrane receptor complex, which is composed of IL-10R1 and IL-10R2, and regulates ...
Sabat R, Grütz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J   +6 more
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Mapping of the interleukin‐10/interleukin‐10 receptor combining site [PDF]

Protein Science, 1998
AbstractThe discontinuous interleukin‐10(IL‐10)/interleukin‐10 receptor (IL‐10R) combining site was mapped using sets of overlapping peptides derived from both binding partners bound to continuous cellulose membranes. Low affinity binding of single regions of the discontinuous contact sites on IL‐10 and IL‐10R could be identified due to (1) high ...
Hans-Dieter Volk, Robert Sabat, Ulrich Reineke, Jens Schneider-Mergener   +3 more
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Interleukin-10 in the intestine [PDF]

Gut, 1997
See article on page215 Cytokines are small glycoprotein mediators involved in communication between cells. Immunological responses are, to a high degree, regulated and directed by specific cytokines. The simultaneous action of different cytokines, as well as their sequential interaction with target cells, seems to be of pivotal importance for an ...
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Comparison of spleen characterization and plasma levels of interleukin 6 and 10 in obese and healthy individuals [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Spleen is one of the organs that has great importance in Iranian traditional medicine due to its relationship with obesity. Therefore, in this study, we aim to investigate spleen characterization and plasma levels of interleukin 6 ...
Mahdis Tanzifi, Mohammad Yousofpour, Amirsaeed Hosseini, Jamshid Yazdani Chrati, Tahereh Amirian   +4 more
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Interleukin-10 in Human Milk [PDF]

Pediatric Research, 1995
The concentrations of immunoreactive IL-10 in the aqueous fraction of 20 specimens of human milk obtained during the first 80 h of lactation and stored at -60 degrees C ranged from 66 to 9301 pg/mL (mean +/- SD, 3304 +/- 3127 pg/mL). IL-10 was present also in the lipid layer of milk.
Helen E. Rudloff, Frank C. Schmalstieg, Kimberly H. Palkowetz, Roberto P. Garofalo, Fang C Mei, Armond S. Goldman, Sadhana Chheda, David K. Rassin   +7 more
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Blood concentrations of endothelin, interleukins 6 and 10 in men with diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2021
Background. Pathological activation of cytokines is one of the key links in the pathogenesis of diabetes mellitus (DM) and the development of its complications, in particular from the cardiovascular system.
E.V. Luchytskiy, V.E. Luchytskiy, G.A. Zubkova, V.M. Rybalchenko, I.I. Skladanna   +4 more
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Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

eLife, 2017
Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling
Naresh S Redhu, Vasudevan Bakthavatchalu, Evan A Conaway, Dror S Shouval, Amy Tsou, Jeremy A Goettel, Amlan Biswas, Chuanwu Wang, Michael Field, Werner Muller, Andre Bleich, Ning Li, Georg K Gerber, Lynn Bry, James G Fox, Scott B Snapper, Bruce H Horwitz   +16 more
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Epigenetic Changes Associated With Interleukin-10 [PDF]

Frontiers in Immunology, 2020
IL-10 is a regulator of inflammation and immunosuppression. IL-10 regulates a variety of immune cells to limit and stop the inflammatory response, and thus plays an important role in autoimmune diseases, inflammatory diseases and cancer. IL-10 is closely related to epigenetic modification, in which changes in DNA methylation of IL-10 gene can affect ...
Mengsha Zou, Zhonghua Zheng, Tianyi Huang, Shiwei Duan, Tong Gao, Gang Huang, Yuhao Zou   +6 more
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Cytokine profiling for Egyptian diabetic patients with nephropathy

Journal of Medicine in Scientific Research, 2022
Background Evidence suggests that poor glycemic control is significantly associated with the development of microvascular complications of diabetes such as nephropathy.
Samar M Samir, Abdel R B. Abdel Gaffar, Ibrahim A Emara, Rania Hassan Mohamed   +3 more
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Interleukin-10 stiffens the heart [PDF]

Journal of Experimental Medicine, 2018
Cardiac-resident macrophages are a diverse population of cells that have a critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.
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