Results 91 to 100 of about 3,159,504 (378)

Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation

Scientific Reports, 2018
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas   +6 more
doaj   +1 more source

The Interleukin-17 Gene of Herpesvirus Saimiri [PDF]

Journal of Virology, 1998
ABSTRACTIn comparison to wild-type herpesvirus saimiri, viral interleukin-17 gene knockout mutants have unaltered behavior regarding viral replication, T-cell transformation in vitro, and pathogenicity in cottontop tamarins. Thus, this gene is not required for T-cell lymphoma induction but may contribute to apathogenic viral persistence in the natural ...
Bernhard Fleckenstein, Jacques Banchereau, Serge Lebecque, Helmut Fickenscher, Jonathan L. Heeney, Christian Hiller, François Fossiez, Andrea Knappe, Henk Niphuis, Brigitte Rosenwirth, Mathias Thurau, Sabine Wittmann, Eva-Maria Kuhn   +12 more
openaire   +3 more sources

Targeting inflammatory pathways in axial spondyloarthritis. [PDF]

, 2019
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
core  

Interleukin-17 regulation: an attractive therapeutic approach for asthma [PDF]

, 2010
Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence
A Awasthi, A Barczyk, A Gottlieb, A Jatakanon, A Lindén, A Saleh, BM Vanaudenaerde, BM Wittig, BP Kota, BP Pappu, C Herbert, CK Wong, CN Serhan, CY Kao, D Toy, DM Bullens, DM Murphy, E Bettelli, E Bettelli, E Lockhart, E Rouvier, EA Rickel, EV Acosta-Rodriguez, F Benchetrit, F Fossiez, F Huang, F McAllister, F Shen, G Murugaiyan, GP Anderson, H Hoshino, H Park, H Wakashin, H Wakashin, HC Hsu, HH Uhlig, II Ivanov, IM Adcock, J Chakir, J Louten, J Peng, J Schwartz, J Witowski, JD Milner, JF Alcorn, JK Kolls, K Nakagome, KS Lee, L McKinley, L Probert, L Wei, LE Harrington, LE Harrington, M Imamura, M Kawaguchi, M Laan, M Laan, M Numasaki, M Veldhoen, MC Berin, MJ McGeachy, ML Michel, MS Rahman, N Krishnamoorthy, O Haworth, O Prause, P Miossec, P Miossec, P Ye, PW Hellings, R Afshar, R Burakoff, R He, R Ma, R Nurieva, R Schwandner, RE Kuestner, RH Wilson, S Fujino, S Ivanov, S Molet, S Nakae, S Phipps, S Schnyder-Candrian, S Yokota, SH Chang, SJ Ballantyne, SJ Park, SJ Park, SL Gaffen, SL Gaffen, SM Hu, SR Kim, ST Holgate, ST Holgate, T Hashimoto, T Korn, T Li, T Shalom-Barak, V Pascual, W Ouyang, X Li, Y Chen, Y Chung, Y Iwakura, Y Minegishi, Y Qian, Y Zhao, YC Sun, YF Yeh, YS Kim, Z Yao, Z Yao   +112 more
core   +2 more sources

T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis [PDF]

, 2020
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the progressive loss of axonal myelin in several areas of the central nervous system (CNS) that is responsible for clinical symptoms such as muscle spasms, optic neuritis ...
Amormino, Carola, Frascolla, Simone, Kunkl, Martina, Tuosto, Loretta, Volpe, Elisabetta   +4 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Uric Acid Potential Role in Systemic Inflammation and Negative Symptoms After Acute Antipsychotic Treatment in Schizophrenia

Frontiers in Psychiatry, 2022
Uric acid (UA) has been shown to have neuroprotective or neurotoxic properties, in relation to specific tissues and diseases that have been studied. Previous studies provided contradictory results on the role of UA in schizophrenia as a neurodegenerative
Milica M. Borovcanin, Slavica Minic Janicijevic, Natasa R. Mijailovic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic, Katarina Vesic   +5 more
doaj   +1 more source

Interleukin-17 as a Therapeutic Target in Psoriasis [PDF]

, 2014
A psoríase é uma doença crónica, inflamatória, imunomediada que afecta cerca de 1-3% da população geral. O avanço no conhecimento da patogénese da psoríase levou ao desenvolvimento de novos fármacos direccionados para vias imunitárias mais específicas ...
Filipe, P., Torres, T.
core  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Investigating the Effect of Endurance Training on Tumor Level of IL-8 and Serum Level of IL-17 in Female Mice with Breast Cancer [PDF]

Journal of Fasa University of Medical Sciences, 2015
Background & Objectives: Breast cancer is nowadays one of the most harmful threats to women’s health. However, exercise training plays an adjuvant role in breast cancer (Adjuvant also means preventive. So, no need to repeat preventing.). Therefore,
AR Kazemi, H Agha Alinejad, R Eslami, P Ehsan, R Baghaei, R Dabaghzadeh, M Ghanbarzadeh   +6 more
doaj   +1 more source