Results 11 to 20 of about 3,298,250 (374)

Interleukin‐17 and ischaemic stroke [PDF]

Immunology, 2020
SummaryInterleukin‐17 (IL‐17) is a cytokine family that includes 6 members, IL‐17A through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to their receptors (IL‐17Rs), IL‐17 activates the intracellular signalling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple
Qiaohui Zhang, Yan Liao, Zhenquan Liu, Yajie Dai, Yunxin Li, Yue Li, Yibo Tang   +6 more
openaire   +3 more sources

Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension [PDF]

Nature Neuroscience, 2023
Monica M. Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola   +12 more
openalex   +2 more sources

The role of interleukin-17 in inflammation-related cancers. [PDF]

Front Immunol
Emerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer.
Zhang X, Li B, Lan T, Chiari C, Ye X, Wang K, Chen J.   +6 more
europepmc   +2 more sources

Interleukin-17 governs hypoxic adaptation of injured epithelium

Science, 2022
Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is insufficient to trigger HIF1α in damaged epithelium.
P. Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, K. Mansfield, Brandon Hsieh, Douglas E Biancur, Samantha B. Larsen, M. Cammer, Dongqing Li, N. Landén, C. Loomis, A. Heguy, Anastasia N. Tikhonova, A. Tsirigos, S. Naik   +15 more
semanticscholar   +1 more source

Interleukin-17 family members in health and disease

International Immunology, 2021
The interleukin-17 (IL-17) family consists of six family members (IL-17A–IL-17F) and all the corresponding receptors have been identified recently.
S. Chung, Xiaoxiao Ye, Y. Iwakura
semanticscholar   +1 more source

Interleukin-17 as a potential therapeutic target for chronic pain

Frontiers in Immunology, 2022
Chronic pain remains to be a clinical challenge and is recognized as a major health problem with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is opioids, which are often accompanied by unwanted psychoactive side ...
Xiaojuan Jiang, Ruihao Zhou, Yujun Zhang, Tao Zhu, Qian Li, WeiYi Zhang   +5 more
semanticscholar   +1 more source

Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer

Genes, 2022
Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses. Although IL-17 was originally identified as a cytokine that induces protective effects against bacterial and fungal infections, IL-17 can also promote chronic ...
E. Meehan, Kepeng Wang
semanticscholar   +1 more source

Interleukin‐17—A multifaceted cytokine in viral infections

Journal of Cellular Physiology, 2021
Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for viral
Utkarsha Sahu, D. Biswas, V. Prajapati, Anirudh K. Singh, M. Samant, P. Khare   +5 more
semanticscholar   +1 more source

Role of Interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression [PDF]

, 2010
Background: The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition, response will be often lost when treatment is stopped. These clinical aspects indicate that other
A Maitra, Anne Tournadre, B Bennett, B Gao, D Alessi, D Borderie, D Borderie, D Eizirik, D Lacey, D Toy, David Boyle, Derya Unutmaz, E Bettelli, E Lubberts, E Nadav, Erik Lubberts, F Arnett, G Firestein, G Page, Gaelle Gonzales, Gary S. Firestein, H Hsu, H Nakamura, J Anolik, J Dufour, J Lee, K Aupperle, L Harrington, M Kaneko, M Kikkert, M Koenders, M Leech, M Toh, M Toh, M Toh, M Toh, Marije I. Koenders, MI Koenders, Myew-Ling Toh, N Yagishita, P Miossec, Pierre Miossec, Q Chen, R Swandner, S Chang, S Cohen, S Hwang, S Hymowitz, S Oyadomari, S Yamasaki, S Zrioual, S Zrioual, T Amano, T Amano, T Gotoh, Wim B. van den Berg, Y Qian, Yuan Zhou, Z You   +58 more
core   +13 more sources

Role of Interleukin-17 in Acute Pancreatitis

Frontiers in Immunology, 2021
Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by systemic manifestations that are generally associated with a poor prognosis. Many cytokines contribute to pancreatic tissue damage and cause systemic injury.
Guanqun Li, Hongze Chen, Liwei Liu, Peng Xiao, Yu Xie, Xinglong Geng, Tao Zhang, Yang Zhang, T. Lu, H. Tan, Le Li, Bei Sun   +11 more
semanticscholar   +1 more source