Results 11 to 20 of about 568,849 (242)

Interleukin-17 is required for control of chronic lung infection caused by Pseudomonas aeruginosa [PDF]

, 2016
Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis (CF) and other chronic lung diseases. Cytokines of the IL-17 family have been proposed as important in the host response to P. aeruginosa infection through augmenting
Bayes, Hannah K., Evans, Thomas J., Ritchie, Neil D.   +2 more
core   +1 more source

Faecalibacterium prausnitziiinhibits interleukin-17 to ameliorate colorectal colitis in rats [PDF]

, 2014
© 2014 Zhang et al. Results: The culture supernatant of F. prausnitzii increased plasma anti-Th17 cytokines (IL-10 and IL-12) and suppressed IL-17 levels in both plasma and colonic mucosa, with ameliorated colonic colitis lesions.
Chen, H, Hong, N, Qiu, X, Yang, X, Yang, Y, Yu, C, Zhang, H, Zhang, M   +7 more
core   +1 more source

Interleukin-17 Expression in the Barrett’s Metaplasia-Dysplasia-Adenocarcinoma Sequence [PDF]

, 2012
Original Research ArticleIntroduction. This pilot study evaluated the expression of the proinflammatory cytokine IL-17 along the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence by establishing the expression levels of IL-17 in columnar epithelium,
Bannister, Jim R., Deol-Poonia, Ranjeev K., Eccleston, David W., Hughes, Stephen F., Khan, Abdul L.   +4 more
core   +2 more sources

Targeting interleukin-17 receptors

Oncotarget, 2015
During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee, Heng-Hsiung, Wu, Chun-Kai, Huang   +2 more
openaire   +2 more sources

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami, Benderdour, Chu, Collins, Conti, Cooke, Fang, Feng, Goodridge, Goodridge, Goodridge, Gulen, Harnett, Harrington, Ito, Ivanov, Kelchtermans, Kenny, Koenders, Koshy, Kulkarni, Langrish, Lubberts, Marshall, Martin, McInnes, Murugaiyan, Nakae, Naor, Niedbala, Petermann, Pickens, Price, Reynolds, Roark, Sato, Shahrara, Shibata, Staschke, Sutton, Szanto, Takayanagi, Tanaka, Vermeire, Whelan, Xu, Xu, Yago   +47 more
core   +1 more source

Interleukin-17: A Revisited Study [PDF]

International Journal of Immunopathology and Pharmacology, 2004
Cytokine is a term used for a large group of proteins that are produced by a variety of cells in the body and act to stimulate, or inhibit, the functions of the same cells that produce them or of other cell types. The IL-17 family members are different in expressions and proinflammatory responses.
HUANG SH, FRYDAS S, CONTI, Pio, KEMPURAJ D, BARBACANE, Renato Carmine, GRILLI, Alfredo, BOUCHER W, LETOURNEAU R, PAPADOPOULOU N, DONELAN J, MADHAPPAN B, THEOHARIDES TC, DE LUTIIS, Maria Anna, RICCIONI, Graziano, SABATINO, Giuseppe   +14 more
openaire   +3 more sources

Airway neutrophils and interleukin-17 [PDF]

European Respiratory Journal, 2000
It is well known that exacerbations of obstructive airways disease such as asthma and chronic obstructive pulmonary disease are associated with an increased number of neutrophils in the airways. However, the mechanisms behind this phenomenon are poorly understood.
A, Lindén, H, Hoshino, M, Laan
openaire   +2 more sources

The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis [PDF]

, 2014
S-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth infection.
Harnett, Margaret, Harnett, William, Pineda, Miguel Angel   +2 more
core   +1 more source

T helper cell subsets specific for pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis [PDF]

, 2014
Background: We set out to determine the magnitude of antigen-specific memory T helper cell responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis.
AJ Vallis, AL Gurney, B Stockinger, BJ Stoodley, CE Zielinski, DG Downey, Dominik Hartl, EV Acosta-Rodriguez, F Ratjen, GF Sonnenberg, GF Sonnenberg, Gordon MacGregor, GP Priebe, Hannah K. Bayes, HL Tan, K Chen, K Wolk, L Martinez-Solano, M Brodlie, M Wuthrich, N Ota, N Rieber, PJ Dubin, R Basu, RB Markham, RG Wunderink, RT Sadikot, S Eyerich, S Trifari, SJ Aujla, SL Gaffen, SM Rowe, Stephen Bicknell, T Duhen, T Sawa, Tom J. Evans, Y Zheng   +36 more
core   +6 more sources

Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease [PDF]

Immunology, 2010
SummaryInterleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL‐17‐producing cells are generated.
Reiko M, Onishi, Sarah L, Gaffen
openaire   +2 more sources