Results 21 to 30 of about 3,159,504 (378)

Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

open access: yesRevista da Sociedade Brasileira de Medicina Tropical, 2021
A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the ...
Patrícia Shu Kurizky   +6 more
doaj   +1 more source

Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans

open access: yesScience Translational Medicine, 2020
Interleukin 17 and senescent cells regulate fibrosis in the foreign body response to synthetic material implants. Elucidating the foreign body response Synthetic materials are the building blocks for medical devices and implants but can induce a foreign ...
Liam Chung   +19 more
semanticscholar   +1 more source

Interleukin-17 Contributes to Chikungunya Virus-Induced Disease

open access: yesmBio, 2022
Alphaviral arthritides caused by mosquito-borne arboviruses such as chikungunya virus (CHIKV) can persist for months after the initial acute disease.
Xiang Liu   +10 more
doaj   +1 more source

Interleukin 17 in vascular inflammation [PDF]

open access: yesCytokine & Growth Factor Reviews, 2010
Interleukin (IL)-17 (also known as IL-17A) is produced by activated T cells. It is a marker cytokine of the T(H₁₇) lineage. IL-17 production is induced in infections, autoimmune diseases and other inflammatory events. IL-17 is involved in host defense, but also inflammatory tissue destruction.
Sibylle von Vietinghoff, Klaus Ley
openaire   +2 more sources

The comparison of the salivary concentration of interleukin-17 and interleukin-18 in patients with chronic periodontitis and healthy individuals

open access: yesDental Research Journal, 2020
Background: Regarding the prevalence and importance of periodontal disease and the potential of salivary biomarkers for the early diagnosis of these diseases, this study was conducted to compare salivary concentrations of Interleukin-17 (IL-17) and ...
Surena Vahabi   +2 more
doaj   +1 more source

Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

open access: yesJournal of Experimental Medicine, 2020
IL17 cross-talk with pancreatic cancer cells orchestrates neutrophil recruitment and activation of Padi4-dependent NETosis, resulting in immune spatial remodeling and immunosuppression reversal.
Yu Zhang   +21 more
semanticscholar   +1 more source

Paradoxical gastrointestinal effects of interleukin-17 blockers

open access: yesAnnals of the Rheumatic Diseases, 2020
Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis.
M. Fauny   +8 more
semanticscholar   +1 more source

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

open access: yes, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M.   +5 more
core   +1 more source

Current concepts in the pathogenesis of spondyloarthritis

open access: yesIndian Journal of Rheumatology, 2020
Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us ...
Nibha Jain, Arumugam Moorthy
doaj   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

open access: yes, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources

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