The evolution of IL-4 and IL-13 and their receptor subunits [PDF]
, 2015 Peer ...
Secombes, Christopher J., Wang, Tiehui
core +1 more source
Turkderm Turkish Archives of Dermatology and Venereology, 2022 Brodalumab is a human monoclonal antibody that inhibits interleukin-17 (IL-17) pathway by binding to IL-17 receptor. In clinical trials, a PASI75 response has been achieved in 82-84% of the patients at week 12.
Murat Borlu
doaj +1 more source
Interleukin‐17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin‐17 receptors in rodents [PDF]
Arthritis & Rheumatism, 2012 AbstractObjectiveInterleukin‐17 (IL‐17) is considered a proinflammatory cytokine, but whether neuronal IL‐17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL‐17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL‐17 is antinociceptive.MethodsWe ...
Frank, Richter +7 more
openaire +2 more sources
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. [PDF]
, 2017 Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life.
Alpdogan, Onder +8 more
core +3 more sources
Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]
, 2016 Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina +9 more
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Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents
Cellular Physiology and Biochemistry, 2017 Background/Aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune ...
Ao-Wang Qiu +2 more
doaj +1 more source
Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
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Interleukin 17 Receptor a Haplotype Analysis in Chronic Spontaneous Urticaria [PDF]
, 2020 Abstract Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease ...
Hesham Nada +6 more
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Soluble ST2 levels and left ventricular structure and function in patients with metabolic syndrome [PDF]
, 2016 Background: A biomarker that is of great interest in relation to adverse cardiovascular events is soluble ST2 (sST2), a member of the interleukin family.
Beunza, Maite +14 more
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Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy [PDF]
Korean Journal of Pediatrics, 2010 Purpose : Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN).
Seung-Ah Baek +3 more
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