Results 11 to 20 of about 567,676 (278)
Journal of Leukocyte Biology, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
Gracie, J.A. +2 more
core +6 more sources
Interleukin-18 and interleukin-18 Binding Protein
Frontiers in Immunology, 2013 Interleukin-18 (IL 18) is a member of the IL 1 family of cytokines. Increasing reports have expanded the role of IL 18 in mediating inflammation in animal models of disease using IL 18 deficient mice, neutralization of IL 18 or deficiency in the IL 18 ...
Charles eDinarello +6 more
doaj +2 more sources
Interleukin 18 in the CNS [PDF]
Journal of Neuroinflammation, 2010 Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory ...
Sugama Shuei +3 more
doaj +5 more sources
Interleukin-18 in Inflammatory Kidney Disease [PDF]
Frontiers in Medicine, 2021 Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj +3 more sources
Interleukin-18 and COVID-19. [PDF]
Epidemiol Infect, 2021 Abstract Vulnerability to coronavirus disease (COVID)-19 varies due to differences in interferon gamma (IFNγ) immunity. We investigated whether a key modifiable interferon precursor, interleukin-18, was related to COVID-19, overall and by severity, using Mendelian randomisation.
Schooling CM, Li M, Au Yeung SL.
europepmc +4 more sources
EMBO Molecular Medicine, 2021 The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation.
Daisuke Watanabe +2 more
doaj +1 more source
International Heart Journal, 2018 A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study. Demographic and clinical data were
Shiying Wang +3 more
openaire +4 more sources
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +1 more source
Targeting interleukin 18 with interleukin 18 binding protein [PDF]
Annals of the Rheumatic Diseases, 2000 A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of ...
openaire +2 more sources
cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]
, 2000 By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
AHN H.-J. +13 more
core +1 more source