Results 21 to 30 of about 5,291,137 (298)

Physiological and molecular effects of interleukin-18 administration on the mouse kidney

Journal of Translational Medicine, 2018
Background The cytokine interleukin-18 was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence to suggest that it has non-immunological effects on physiological functions.
Kyosuke Yamanishi, Keiichiro Mukai, Takuya Hashimoto, Kaoru Ikubo, Keiji Nakasho, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Tetsu Hayakawa, Hiroshi Nojima, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga   +13 more
doaj   +1 more source

Role of interleukin 18 in rheumatoid arthritis [PDF]

, 2003
No abstract ...
Liew, Foo Y., Wei, Xiao-Qing, Liew, F.Y., Wei, X.Q., McInnes, I. B.   +4 more
core   +1 more source

Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018
Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in ...
Berk Arapi, Burcu Bayoğlu, Müjgan Cengiz, Ahmet Dirican, Serkan Burç Deser, Yerik Junusbekov, Caner Arslan   +6 more
doaj   +1 more source

Diagnostic values of serum IL-17A and IL-18 in Rheumatoid arthritis and Correlation with treatment

مجلة مركز بحوث التقنيات الاحيائية, 2022
Background: Rheumatoid arthritis (RA) is an autoimmune disorder that involves autoantibodies attacking and weakening joints. RA is characterized by leukocyte (Monocyte, Lymphocyte mast cell .etc) infiltrations into the synovial compartment leading to ...
Noorhan H. Yousif, Shaima R. Ibraheem , Aseel shakir Mahmood   +2 more
doaj   +1 more source

Priming by recombinant chicken interleukin-2 induces selective expression of IL-8 and IL-18 mRNA in chicken heterophils during receptor-mediated phagocytosis of opsonized and nonopsonized Salmonella enterica serovar enteritidis [PDF]

, 2003
Heterophils, the principal avian polymorphonuclear leukocytes (PMNs) equivalent to the mammalian neutrophil, function as professional phagocytes against bacterial infections, mediate acute inflammation, and respond to cytokine stimulation to aid in ...
Michael H Kogut, Pete Kaiser, Kogut, Michael H, Kaiser, Pete, Lisa Rothwell, Rothwell, Lisa   +5 more
core   +1 more source

Interleukin-18, neutrophils, and ANCA [PDF]

Kidney International, 2006
Hewins et al. show that IL-18 is expressed in the kidneys of patients with ANCA-associated glomerulonephritis, and that IL-18 primes neutrophils via p38 MAPK. These findings suggest a role for IL-18, including IL-18-induced T(H)1 polarization and IFN-gamma production, in the progression of ANCA disease.
Pressler, B.M., Falk, R.J., Preston, C.A.   +2 more
openaire   +2 more sources

Interleukin-18 in Health and Disease [PDF]

International Journal of Molecular Sciences, 2019
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12
Koubun Yasuda, Kenji Nakanishi, Hiroko Tsutsui   +2 more
openaire   +3 more sources

Interleukin 10 And 18 levels in Essential Hypertensive

Journal of Applied Sciences and Environmental Management, 2019
The mechanism underlying a sustained blood pressure elevation and its sequelae on the inflammatory cascades have not been totally unraveled. This research was, in addition to body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP ...
O.O. Odewusi, H.B. Osadolor
doaj   +1 more source

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate [PDF]

, 2004
IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sj&
Blades, Mark C, I. B. Mcinnes, Conigliaro, Paola, Paola Conigliaro, Mcinnes, I, Iain B McInnes, Priori, R, Barone, Francesca; id_orcid, Pittoni, Valerio, M. C. Blades, Pitzalis, C., Mark C Blades, Priori, R., M. Bombardieri, C. Pitzalis, ALESSANDRI, cristiano, Alessandri, C., Cristiano Alessandri, Bombardieri, M, Alessandri, C, VALESINI, Guido, McInnes, I B, Roberta Priori, Valesini, G., R. Priori, Conigliaro, P., Bombardieri, M., F. Barone, Valesini, G, Blades, M.C., P. Conigliaro, Blades, M, Pitzalis, C, V. Pittoni, Blades, M C, Pittoni, P., Pitzalis, Costantino, Michele Bombardieri, Conigliaro, P, Blades, MC, Pittoni, V, Bombardieri, Michele, Priori, Roberta, Barone, F., McInnes, I.B., Guido Valesini, Francesca Barone, McInnes, IB, McInnes, Iain B, Valerio Pittoni, Barone, F, Costantino Pitzalis   +51 more
core   +1 more source

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source