Results 21 to 30 of about 3,908,268 (304)

Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2002
To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment.Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA ...
B, Bresnihan, P, Roux-Lombard, E, Murphy, D, Kane, O, FitzGerald, J-M, Dayer   +5 more
openaire   +3 more sources

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.), Rehart, Stefan, Kalina, Uwe, Kessler, Uta, Kukoc-Zivojnov, Natasa, Kaltwasser, Joachim Peter (Prof. Dr.), Ottmann, Oliver G., Möller, Burkhard   +7 more
core   +1 more source

Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma [PDF]

European Respiratory Journal, 2011
To the Editors: The inflammatory process in allergic asthma is initiated by T-helper (Th) type-2 cells, which produce a repertoire of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13, which are necessary for immunoglobulin (Ig)E production, airway eosinophilia and goblet cell hyperplasia [1].
H, Imaoka, G M, Gauvreau, R M, Watson, S G, Smith, B, Dua, A J, Baatjes, K, Howie, T, Hoshino, K J, Killian, H, Aizawa, P M, O'Byrne   +10 more
openaire   +2 more sources

Role of interleukin 18 in rheumatoid arthritis [PDF]

, 2003
No abstract ...
Liew, Foo Y., Wei, Xiao-Qing, Liew, F.Y., Wei, X.Q., McInnes, I. B.   +4 more
core   +1 more source

Physiological and molecular effects of interleukin-18 administration on the mouse kidney

Journal of Translational Medicine, 2018
Background The cytokine interleukin-18 was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence to suggest that it has non-immunological effects on physiological functions.
Kyosuke Yamanishi, Keiichiro Mukai, Takuya Hashimoto, Kaoru Ikubo, Keiji Nakasho, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Tetsu Hayakawa, Hiroshi Nojima, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga   +13 more
doaj   +1 more source

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate [PDF]

, 2004
IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sj&
Blades, Mark C, I. B. Mcinnes, Conigliaro, Paola, Paola Conigliaro, Mcinnes, I, Iain B McInnes, Priori, R, Barone, Francesca; id_orcid, Pittoni, Valerio, M. C. Blades, Pitzalis, C., Mark C Blades, Priori, R., M. Bombardieri, C. Pitzalis, ALESSANDRI, cristiano, Alessandri, C., Cristiano Alessandri, Bombardieri, M, Alessandri, C, VALESINI, Guido, McInnes, I B, Roberta Priori, Valesini, G., R. Priori, Conigliaro, P., Bombardieri, M., F. Barone, Valesini, G, Blades, M.C., P. Conigliaro, Blades, M, Pitzalis, C, V. Pittoni, Blades, M C, Pittoni, P., Pitzalis, Costantino, Michele Bombardieri, Conigliaro, P, Blades, MC, Pittoni, V, Bombardieri, Michele, Priori, Roberta, Barone, F., McInnes, I.B., Guido Valesini, Francesca Barone, McInnes, IB, McInnes, Iain B, Valerio Pittoni, Barone, F, Costantino Pitzalis   +51 more
core   +1 more source

Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Balkan Medical Journal, 2018
Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in ...
Berk Arapi, Burcu Bayoğlu, Müjgan Cengiz, Ahmet Dirican, Serkan Burç Deser, Yerik Junusbekov, Caner Arslan   +6 more
doaj   +1 more source

Interleukin-18, neutrophils, and ANCA [PDF]

Kidney International, 2006
Hewins et al. show that IL-18 is expressed in the kidneys of patients with ANCA-associated glomerulonephritis, and that IL-18 primes neutrophils via p38 MAPK. These findings suggest a role for IL-18, including IL-18-induced T(H)1 polarization and IFN-gamma production, in the progression of ANCA disease.
Pressler, B.M., Falk, R.J., Preston, C.A.   +2 more
openaire   +2 more sources

The circulating level of interleukins 6 and 18 in ischemic and idiopathic dilated cardiomyopathy [PDF]

Journal of Cardiovascular and Thoracic Research, 2019
Introduction: By aging population, the heart failure and its life-threatening complications have become an enormous issue in public health. Regarding the inflammation as a major contributing pathological factor, the determination of most important ...
Mahdiyar Iravani Saadi, Mohammad Ali Babaee Beigi, Maryam Ghavipishe, Maryam Tahamtan, Bita Geramizadeh, Abdolhossein Zare, Ramin Yaghoobi   +6 more
doaj   +1 more source

Interleukin-18 in Health and Disease [PDF]

International Journal of Molecular Sciences, 2019
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12
Koubun Yasuda, Kenji Nakanishi, Hiroko Tsutsui   +2 more
openaire   +3 more sources