Results 21 to 30 of about 613,671 (263)

Interleukin-18, neutrophils, and ANCA [PDF]

Kidney International, 2006
Hewins et al. show that IL-18 is expressed in the kidneys of patients with ANCA-associated glomerulonephritis, and that IL-18 primes neutrophils via p38 MAPK. These findings suggest a role for IL-18, including IL-18-induced T(H)1 polarization and IFN-gamma production, in the progression of ANCA disease.
Pressler, B.M., Falk, R.J., Preston, C.A.   +2 more
openaire   +2 more sources

Interleukin-18 in Health and Disease [PDF]

International Journal of Molecular Sciences, 2019
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. Therefore, IL-12
Koubun Yasuda, Kenji Nakanishi, Hiroko Tsutsui   +2 more
openaire   +3 more sources

Interleukin 10 And 18 levels in Essential Hypertensive

Journal of Applied Sciences and Environmental Management, 2019
The mechanism underlying a sustained blood pressure elevation and its sequelae on the inflammatory cascades have not been totally unraveled. This research was, in addition to body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP ...
O.O. Odewusi, H.B. Osadolor
doaj   +1 more source

Interleukin-18 in Human Milk [PDF]

Pediatric Research, 2001
We analyzed IL-18 levels of human milk. Colostrum contained significantly higher levels of IL-18 compared with early milk and mature milk. By stepwise multiple linear regression analysis, preterm delivery and pregnancy complications of mothers significantly correlated with high levels of IL-18 in human milk (p = 0.0007 and 0.0018, respectively).
Y, Takahata, H, Takada, A, Nomura, K, Ohshima, H, Nakayama, T, Tsuda, H, Nakano, T, Hara   +7 more
openaire   +2 more sources

The circulating level of interleukins 6 and 18 in ischemic and idiopathic dilated cardiomyopathy [PDF]

Journal of Cardiovascular and Thoracic Research, 2019
Introduction: By aging population, the heart failure and its life-threatening complications have become an enormous issue in public health. Regarding the inflammation as a major contributing pathological factor, the determination of most important ...
Mahdiyar Iravani Saadi, Mohammad Ali Babaee Beigi, Maryam Ghavipishe, Maryam Tahamtan, Bita Geramizadeh, Abdolhossein Zare, Ramin Yaghoobi   +6 more
doaj   +1 more source

Beneficial and detrimental roles of NLRs in carcinogenesis

Frontiers in Immunology, 2013
Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic mutations, tumor promotion, and angiogenesis. Tumor promoting inflammation is driven by many factors including the presence of the pro-inflammatory cytokines interleukin (
Ann M Janowski, Ryan eKolb, Weizhou eZhang, Fayyaz S Sutterwala   +3 more
doaj   +1 more source

Analytical Value of Cell-Free DNA Based on Alu in Psychiatric Disorders

Frontiers in Psychiatry, 2020
Psychiatric disorders impose a huge burden on individuals, families, and society. The Alu repeat sequence is a member of the short interspersed nuclear element (SINE) family of mammalian genomes, however, its expression pattern and role in psychiatric ...
Jing Qi, Ling-Yun Chen, Xian-Juan Shen, Shao-Qing Ju   +3 more
doaj   +1 more source

The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis

Frontiers in Immunology, 2023
BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Laura M. Merlo Pich, Laura M. Merlo Pich, Laura M. Merlo Pich, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Assunta Caruso, Assunta Caruso, Assunta Caruso, Emiliana Rodriguez, Emiliana Rodriguez, Emiliana Rodriguez, Cem Gabay, Cem Gabay, Cem Gabay   +17 more
doaj   +1 more source

Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

Journal of the Formosan Medical Association, 2011
Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu, Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu   +5 more
doaj   +1 more source

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation [PDF]

Nature Immunology, 2006
T helper type 1 (T$_{H}$1) lymphocytes are considered to be the main pathogenic cell type responsible for organ-specific autoimmune inflammation. As interleukin 18 (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous system inflammation.
Gutcher, Ilona, Urich, Eduard, Wolter, Karina, Prinz, Marco, Becher, Burkhard   +4 more
openaire   +5 more sources