Results 1 to 10 of about 22,453,438 (395)

Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly

Noise and Health
Context: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.
Fernanda P. Cordeiro, Luciana L.M. Marchiori, Denilson C. Teixeira, Rodrigo A.C. Andraus, Regina Célia Poli-Frederico   +4 more
doaj   +2 more sources

Extracting Mutual Interaction Rules Using Fuzzy Structured Agent-based Model of Tumor-Immune System Interactions [PDF]

Journal of Biomedical Physics and Engineering, 2021
Background: There are many studies to investigate the effects of each interacting component of tumor-immune system interactions. In all these studies, the distinct effect of each component was investigated.
A Allahverdy, S Rahbar, H R Mirzaei, M Ajami, A Namdar, S Habibi, J Hadjati, A H Jafari   +7 more
doaj   +1 more source

Low-dose IL-2 improved clinical symptoms by restoring reduced regulatory T cells in patients with refractory rheumatoid arthritis: A randomized controlled trial

Frontiers in Immunology, 2022
BackgroundRegulatory T cells (Tregs) have been found to play crucial roles in immune tolerance. However, the status of Tregs in refractory rheumatoid arthritis (RA) is still unclear.
Jia Wang, Jia Wang, Sheng-Xiao Zhang, Sheng-Xiao Zhang, Jia-Song Chang, Jia-Song Chang, Ting Cheng, Ting Cheng, Xiao-Jing Jiang, Xiao-Jing Jiang, Qin-Yi Su, Qin-Yi Su, Jia-Qi Zhang, Jia-Qi Zhang, Jing Luo, Jing Luo, Xiao-Feng Li, Xiao-Feng Li   +17 more
doaj   +1 more source

Low Dose Interleukin-2 Ameliorates Sjögren’s Syndrome in a Murine Model

Frontiers in Medicine, 2022
Sjögren’s syndrome (SS) is a systemic autoimmune disease with no efficient treatment, and it is associated with dysregulated immune cells and impaired interleukin (IL)-2 signaling. IL-2 is critical for the development and maintenance of Treg cells.
Yifan Wang, Ruiling Feng, Gong Cheng, Bo Huang, Jiayi Tian, Yuzhou Gan, Yuebo Jin, Miao Miao, Xia Zhang, Xiaolin Sun, Jing He, Zhanguo Li   +11 more
doaj   +1 more source

Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

Mediators of Inflammation, 2006
The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers ...
Daria Simcic, Sonja Pezelj-Ribaric, Renata Gržic, Jelena Horvat, Gordana Brumini, Miranda Muhvic-Urek   +5 more
doaj   +2 more sources

Effects of ivermectin on cytokine and immunoglobulin levels in sheep

Revista Colombiana de Ciencias Pecuarias, 2023
Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system.
Rahmi Canbar, Irmak Dik, Muhittin Uslu, Merve Ider, Mustafa-Sedat Arslan, Enver Yazar   +5 more
doaj   +1 more source

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

BMC Medical Genetics, 2020
Background Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD.
Sara Hanaei, Sina Abdollahzade, Maryam Sadr, Mohammad Hossein Mirbolouk, Ehsan Fattahi, Alireza Khoshnevisan, Nima Rezaei   +6 more
doaj   +1 more source

Pro- and Anti-Tumoral Factors Involved in Total Body Irradiation and Interleukin-2 Conditioning in Adoptive T Cell Therapy of Melanoma-Bearing Rag1 Knock-Out Mice

Cells, 2022
In adoptive T cell therapy (ACT), the transfer of tumor-specific T cells is paralleled by the conditioning regimen to increase therapeutic efficacy. Pre-conditioning depletes immune-suppressive cells and post-conditioning increases homeostatic signals to
Seon-Hee Kim, Eun Mi Go, Dong Hoon Shin, Beom K. Choi, Chungyong Han   +4 more
doaj   +1 more source

T Cells, Interleukin-2 and Systemic Lupus Erythematosus—From Pathophysiology to Therapy

Cells, 2022
The phenotypic and functional complexities of T cells engender complicated and often confusing concepts as to how T cells ignite, accelerate and brake the inflammatory processes involved in systemic lupus erythematosus (SLE), let alone the plasticity of ...
Anselm Mak
doaj   +1 more source

Signaling and Function of Interleukin-2 in T Lymphocytes.

Annual Review of Immunology, 2018
The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both
S. Ross, D. Cantrell
semanticscholar   +1 more source