Results 61 to 70 of about 23,125,138 (369)

Immune checkpoint inhibitors in renal cell carcinoma [PDF]

, 2017
The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain.
Jones, Robert J., Ross, Kirsty
core   +1 more source

Influence of spleen meal and hydrolyzed yeast on growth performance, blood cells, antibody titres and IL-2 gene expression in broiler chickens

Journal of Applied Animal Research, 2021
Two experiments were conducted to evaluate spleen meal (SPM) nutritional value and compare its effects and hydrolyzed yeast (HY) in broiler chickens. In experiment 1, nutrient composition and metabolizable energy content of SPM were determined using male
Masoud Pahlavanzadeh, Ali Asghar Sadeghi, Seyed Naser Mousavi, Mohammad Chamani   +3 more
doaj   +1 more source

Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus [PDF]

, 2023
Yi‐Giien Tsai, P. F. Liao, Kai‐Hung Hsiao, Hung‐Ming Wu, Ching‐Yuang Lin, Kuender D. Yang   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly

Noise and Health
Context: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.
Fernanda P. Cordeiro, Luciana L.M. Marchiori, Denilson C. Teixeira, Rodrigo A.C. Andraus, Regina Célia Poli-Frederico   +4 more
doaj   +1 more source

Molecular Remission Using Low-Dose Immunotherapy with Minimal Toxicities for Poor Prognosis IGHV—Unmutated Chronic Lymphocytic Leukemia

Cells, 2020
Chronic lymphocytic leukemia (CLL) accounts for 10% of hematologic malignancies. CLL is a malignancy of CD5+ B cells and it is characterized by the accumulation of small, mature-appearing neoplastic lymphocytes in the blood, bone marrow, and secondary ...
Dipnarine Maharaj, Gayathri Srinivasan, Maria M. Abreu, Meng-Wei Ko, Anahid Jewett, Jacqueline Gouvea   +5 more
doaj   +1 more source

The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: A case control study [PDF]

, 2021
Chen‐Yu Chien, Shu‐Yu Tai, Kuan-Hui Li, Hualing Yang, Leong‐Perng Chan, Edward Hsi, Ling‐Feng Wang, Kuen‐Yao Ho, Ning‐Chia Chang   +8 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models

Frontiers in Immunology
IntroductionHyperthermia is an established adjunct in multimodal cancer treatments, with mechanisms including cell death, immune modulation, and vascular changes.
Barry E. Kennedy, Erin B. Noftall, Cheryl Dean, Alexander Roth, Kate N. Clark, Darren Rowles, Kulbir Singh, Len Pagliaro, Carman A. Giacomantonio, Carman A. Giacomantonio, Carman A. Giacomantonio   +10 more
doaj   +1 more source