Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential [PDF]
Cells, 2023 Brain tumors represent a heterogeneous group of neoplasms involving the brain or nearby tissues, affecting populations of all ages with a high incidence worldwide.
Alberto Repici +9 more
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Regulation of the germinal center and humoral immunity by interleukin-21. [PDF]
J Exp Med, 2020 Here we review the critical and non-redundant functions of IL-21 in regulating humoral immune responses. We particularly focus on studies in natura—from individuals from inborn errors of immunity that impact on IL-21 production and/or function.
Tangye SG, Ma CS.
europepmc +2 more sources
Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells [PDF]
Stem Cells International, 2022 Dysfunctions in adipose tissue cells are responsible for several obesity-related metabolic diseases. Understanding the process of adipocyte formation is thus fundamental for understanding these diseases.
Bruna Cristina Falavinha +7 more
doaj +2 more sources
Peran Reseptor IL-21 (IL-21R) sebagai Target Terapi Pada Penyakit Arteri Perifer [PDF]
Scripta Score Scientific Medical Journal, 2021 Background: Peripheral Artery Disease (PAD) is caused due to the disruption of blood supply to the periphery caused by blockages in the arteries. PAD is a disease that is difficult to detect and the current therapy is still limited to pharmacological ...
Muhammad Luthfi Adnan
doaj +3 more sources
Role of Hemin in the Immune Response of T Follicular Helper Lymphocytes Expressing T-Cell Immunoreceptor with Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Domains, Programmed Cell Death-1, and Interleukin-21 in Allo-Auto Positive and Negative Thalassemia [PDF]
Journal of Blood Medicine, 2023 Betty Agustina Tambunan,1– 3 I Dewa Gede Ugrasena,3,4 Aryati2,3 1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya,
Tambunan BA, Ugrasena IDG, Aryati
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Decreased Serum Levels of Interleukin-4 and Interleukin-21 in New Pemphigus Vulgaris Patients, but Not Chronic Patients With Inactive Disease Compared to Healthy Controls [PDF]
Dermatology Practical & Conceptual, 2021 Background: Pemphigus is a rare group of autoimmune blistering diseases with unknown etiology and unclear pathogenesis. Pemphigus vulgaris (PV) is the most common subtype, and is characterized by ulcerations or flaccid blisters on mucous membranes and on
Pegah Shahbazian +7 more
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Interleukin-21 in cancer immunotherapy [PDF]
OncoImmunology, 2012 Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer.
Stolfi, C +3 more
openaire +7 more sources
Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis [PDF]
BMC Musculoskeletal Disorders, 2021 Background Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines.
Youguo Hao +5 more
doaj +2 more sources
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis [PDF]
Clinical and Experimental Immunology, 2015 Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast‐like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and
Rui Xing +7 more
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Haematologica, 2019 Systemic lupus erythematosus is frequently associated with antiphospholipid syndrome. Patients with lupus-antiphospholipid syndrome are characterized by recurrent arterial/venous thrombosis, miscarriages, and persistent presence of autoantibodies against
Marisa Benagiano +17 more
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