Results 191 to 200 of about 528,114 (310)

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Advanced Materials, EarlyView.
This study presents human in vitro rheumatoid arthritis models using chondrocytes recellularized type II collagen scaffold and 3D‐bioprinted Gelatin‐Matrigel hydrogels with fibroblast‐like synoviocytes, pro‐inflammatory macrophages, and protective barrier macrophages, closely recapitulating key rheumatoid arthritis pathological features.
Huiqun Zhou, Zhen Zhang, Yulei Mu, Liang Ma, Xu Hu, Bangheng Liu, Dong‐An Wang   +6 more
wiley   +1 more source

Interleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation

Iranian Journal of Allergy, Asthma and Immunology, 2015
Inflammation is an important reaction underlying lumbar disc herniation (LDH). Th17 cells play a critical role in immune activation. Interleukin (IL)-21 controls the functional activity of effector T-helper cells and the differentiation of Th17 cells ...
Huawei Xue, Yu Yao, Xiaoying Wang, Feng Zhang, Xingjie Jiang, Jinbao Liu, Hua Wang, Yuqian Li, Xiaodong Wang, Hongbin Li, Jianhua Zhang   +10 more
doaj  

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4 ⁺ T Cells

, 2021
Jernej Pušnik, Stephanie Fischinger, Ulf Dittmer, Stefan Eßer, Marit J. van Gils, Rogier W. Sanders, Galit Alter, Hendrik Streeck   +7 more
openalex   +2 more sources

HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells. [PDF]

AIDS, 2021
Dalel J, Ung SK, Hayes P, Black SL, Joseph S, King DF, Makinde J, Gilmour J, The IAVI Protocol C investigators list .   +8 more
europepmc   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Nonmulberry Silk Fibroin Doping Boosts Charge Transfer and Charge Injection in Aligned Polypyrrole‐Silk Scaffolds for Low‐Voltage Neurostimulation

Advanced Materials Interfaces, EarlyView.
Conductive silk‐polypyrrole scaffolds couple redox stability with cell‐affinitive peptides present innately in an endogenous silk fibroin, enabling optimized electrical stimulation to drive neurite outgrowth. Findings establish electrochemical‐biological link for biomaterial design rules for smart nerve guidance conduits that can provide low voltage ...
Rajiv Borah, Joseph Christakiran Moses, Jnanendra Upadhyay, Jitu Mani Das, Michael G. Monaghan, Biman B. Mandal   +5 more
wiley   +1 more source

Design of a potent interleukin-21 mimic for cancer immunotherapy. [PDF]

Sci Immunol
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D.   +43 more
europepmc   +1 more source

Association between Interleukin-21 Serum Level and IL-21 Genetic Polymorphism with the Cardiovascular Morbidity Risk in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients [PDF]

openalex   +1 more source

Supplementary Figures 1 and 2, Table 1 from A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders

, 2023
John M. Timmerman, John C. Byrd, David Andorsky, Reiko Yamada, Janet Kramer, Natarajan Muthusamy, Naomi Hunder, John M. Pagel   +7 more
openalex   +2 more sources