Results 51 to 60 of about 3,093,388 (334)
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. [PDF]
Immunity, 2008 SummaryAfter activation, CD4+ helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is ...
R. Nurieva +10 more
semanticscholar +2 more sources
Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study [PDF]
, 2014 Background Despite the positive impact of targeted therapies on metastatic renal cell carcinoma (mRCC), durable responses are infrequent and an unmet need exists for novel therapies with distinct mechanisms of action.
Bhatia, Shailender +15 more
core +8 more sources
Aberrant expansion of follicular helper T cell subsets in patients with systemic lupus erythematosus
Frontiers in Immunology, 2022 ObjectiveSystemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by multiple autoantibodies, resulting in multiple organ and tissue damages.
Xin Jin +7 more
doaj +1 more source
Pathogenic role of interleukin-21 in psoriasis [PDF]
Cell Cycle, 2009 Psoriasis is a chronic inflammatory disease of the skin characterized by keratinocyte hyperplasia and dermal infiltration with inflammatory cells. Driving factors the epidermal hyperplasia in psoriasis are not fully understood, but there is evidence that T cell-derived cytokines can be involved. In this article, we focus on the recent data indicating a
CARUSO, ROBERTA +2 more
openaire +4 more sources
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling [PDF]
, 2011 We screened a library of human single-transmembrane proteins (sTMPs), produced by a cell-free system, using a luminescent assay to identify those that can be cleaved by caspase-8 (CASP8). Of the 407 sTMPs screened, only the interleukin-21 receptor (IL21R)
Akagi, Tatsuya +6 more
core +1 more source
Frontiers in Oncology, 2021 Regulatory T cells (Tregs) are immunosuppressive cells involved in antitumor immunity. However, the regulation of Treg generation by inflammation in the tumor microenvironment has not been carefully investigated.
Yi Zhao +26 more
doaj +1 more source
The role of interleukin-21 in HIV infection [PDF]
Cytokine & Growth Factor Reviews, 2012 Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ(c)). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the ...
Savita Pahwa +2 more
openaire +3 more sources
IL-21 receptor expression in human tendinopathy [PDF]
, 2014 The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role.
Campbell, Abigail L. +8 more
core +2 more sources
The Emerging Role of Interleukin-21 in Transplantation [PDF]
Journal of Clinical & Cellular Immunology, 2013 Since its discovery in 2000, IL-21 has been shown to play critical roles in the regulation of both innate and adaptive immune responses. IL-21 is produced predominantly by multiple effector CD4+ T-cell types [T helper 17 (Th17), follicular helper T (TFH), and other activated CD4+ cells] and NKT cells.
Wenhao Chen +3 more
openaire +3 more sources
Interleukin-21 expanded NKDC in vitro reduces the B16F10 tumor growth in vivo [PDF]
, 2013 Innate immunity to tumors is mediated mainly by natural killer cells (NKs) and dendritic cells (DCs). The function of these cells is coordinated by cytokines produced during the inflammatory process.
Bonorino, C. +3 more
core +1 more source