Results 111 to 120 of about 4,841,277 (301)

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation [PDF]

, 2018
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular
A Dixit, A Jäger, A Tanay, A Wagner, AK Björklund, Antonia Wallrapp, Aviv Regev, BD Modena, Brian J. Haas, Bruce D. Levy, C Soneson, CE Prendergast, Christoph S. N. Klose, Christopher Rodman, D Cheng, Daneyal Farouq, Danielle Dionne, David Artis, DF Gudbjartsson, DR Neill, F Gerbe, GX Zheng, I Tirosh, Isaac M. Chiu, J Beale, J von Moltke, JA Hedrick, Jackson Nyman, JC Nussbaum, John J. Trombetta, JT Gaublomme, K Branchfield, K Kurakula, K Moro, K Shekhar, KJ Audrit, L Shan, LA Monticelli, LA Monticelli, M Gury-BenAri, M Moriyama, M Salimi, M Schuliga, M Singer, Matan Hofree, Michael S. Cuoco, ML Robinette, Monika S. Kowalczyk, MR Howitt, MS Kowalczyk, N Habib, NL Bray, NM Heshmat, Orit Rozenblatt-Rosen, Pankaj Baral, Patrick R. Burkett, PG Szekeres, R Satija, Raja-Elie E. Abdulnour, S Picelli, S Talbot, Samantha J. Riesenfeld, T Katsunuma, T Polte, T Sekigawa, Tanel Mahlakõiv, Timothy L. Tickle, TY Halim, Vijay K. Kuchroo, X Gu, Y Huang, YJ Chang   +71 more
core   +1 more source

Mechanism of interleukin‐25 (IL‐17E)‐induced pulmonary inflammation and airways hyper‐reactivity

Clinical & Experimental Allergy, 2006
SummaryBackground IL‐25, a novel member of the IL‐17 cytokine family, promotes CD4+ T‐helper 2 lymphocyte‐like (Th type‐2) inflammatory responses in the lung. Although IL‐25 up‐regulates IL‐13 in the lung, the contribution of this and other type 2 cytokine signalling pathways to the induction and persistence of airways hyper‐reactivity (AHR) and ...
Sharkhuu, T., Matthaei, K. I., Forbes, E., Mahalingam, S., Hogan, S. P., Hansbro, P. M., Foster, P. S.   +6 more
openaire   +3 more sources

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Ixekizumab Survival in Heavily Pretreated Patients with Psoriasis: A Two-year Single-centre Retrospective Study

Acta Dermato-Venereologica, 2020
The long-term effect of intra-anti-interleukin-17-class switch on drug survival is unclear. The aim of this study was to evaluate the efficacy and long-term survival of ixekizumab in bio-experienced psoriatic patients with and without previous exposure ...
Shany Sherman, Ory Zloczower, Yehonatan Noyman, Iris Amitay-Laish, Emmilia Hodak, Lev Pavlovsky   +5 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Catalytic receptors [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +5 more sources

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2019
Background Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate the processes of liver diseases, including hepatocellular carcinoma (HCC).
Qiao Li, Lei Ma, Shunli Shen, Yu Guo, Qinghua Cao, Xiuqin Cai, Juan Feng, Yuan Yan, Tianyu Hu, Shiya Luo, Lin Zhou, Baogang Peng, Zhonghan Yang, Yunpeng Hua   +13 more
doaj   +1 more source

The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex [PDF]

, 2011
Background The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known.
Gary M Hunninghake, Jen-hwa Chu, Sunita S Sharma, Michael H Cho, Blanca E Himes, Angela J Rogers, Amy Murphy, Vincent J Carey, Benjamin A Raby   +8 more
core   +2 more sources

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source