Results 101 to 110 of about 4,841,277 (301)

Personalized medicine with biologics for severe type 2 asthma : current status and future prospects [PDF]

, 2017
Asthma affects more than 300 million people worldwide and poses a large socioeconomic burden, particularly in the 5% to 10% of severe asthmatics. So far, each entry of new biologics in clinical trials has led to high expectations for treating all severe ...
Blanchetot, Christophe, Brusselle, Guy, de Haard, Hans, Godar, Marie, Lambrecht, Bart   +4 more
core   +3 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond

Frontiers in Immunology, 2018
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development.
Nicolo Costantino Brembilla, Luisa Senra, Wolf-Henning Boehncke, Wolf-Henning Boehncke   +3 more
doaj   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Role of Interleukin-25 in allergic airway inflammation and vascular damage

Inflammation and Regeneration, 2011
T helper 2 (Th2) cells induce allergic inflammation through the production of Th2 cytokines such as IL-4, IL-5, and IL-13. In addition, it has been demonstrated that IL-25 (IL-17E) is a product of activated Th2 cells and initiates and augments Th2-type immune responses. Moreover, recent studies have shown that IL-25 is produced by a number of cell type
Hiroshi Nakajima, Saki Kawashima, Tomohiro Tamachi, Kentaro Takahashi, Koichi Hirose   +4 more
openaire   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients

Journal of the Pakistan Medical Association
Objective: To explore the clinical significance of interleukin-1 and interleukin-6 in the development of lateralized temporal epilepsy. Method: The prospective study was conducted from January to April of 2022 at the Neurology Department of Training ...
Asuman Orhan Varoglu, Aysenur Avarisli, Havva Keskin, Hayriye Erman   +3 more
doaj   +1 more source

Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK [PDF]

, 2015
Selectins are glycan-binding adhesion molecules that mediate the initial steps of leukocyte recognition of endothelium. Cytokines control numerous aspects of CD4 Th cell differentiation, but how cytokines control the induction of ligands for E- and P ...
Awe, Olufolakemi, Ebel, Mark E., Kansas, Geoffrey S., Kaplan, Mark H.   +3 more
core   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Relationship of serum Vitamin D concentrations with Adipokines and Cardiometabolic risk among non-Hispanic black type 2 diabetic and non-diabetic subjects: a cross-sectional study

BMC Nutrition, 2018
Background To report the association of serum 25-hydroxyvitamin D [25(OH)D] and its association with adipokines and cardiometabolic risk factors in Haitian Americans (HA) and African Americans (AA) by ethnicity and type 2 diabetes (T2D) status. Methods A
Janet Antwi, Fatma Huffman, Stacey Sullivan   +2 more
doaj   +1 more source