Results 81 to 90 of about 4,841,277 (301)

Interleukin‐22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110834/1/imm12414 ...
Bergin, Ingrid L., Carlson, Paul E., Falkowski, Nicole R., Frank, Charles R., Huffnagle, Gary B., McDermott, Andrew J., McDonald, Roderick A., Sadighi Akha, Amir A., Theriot, Casey M., Young, Vincent B.   +9 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection [PDF]

, 2012
Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection ...
Bauer, Bromberg, Byers, Byers, C. Page, Clausen, Collard, Daley, Dasgupta, Ding, Durbin, Durbin, Eschrich, Franks, Frieman, Frieman, Gordon, Gross, Han, Hussain, Jakubzick, K. Matthews, Kaganoi, Khodarev, Kim, Klover, Kobasa, Kollef, Kopecky-Bromberg, Ksiazek, Kuiken, Kurowska-Stolarska, L. Goicochea, L. Hennighausen, Lau, Lee, Levy, Liddiard, Lillemeier, Lopez-Navarrete, M. Frieman, M. J. Holtzman, Mauad, Meduri, Meneghin, Meraz, Mishra, Mora, Moreira, Moreno, Narayanan, Netland, Ohtsubo, P. Klover, Pechkovsky, Peiris, Perrone, Pesce, Pierce, Pierrakos, Raes, Raes, Reiman, Roberts, Rock, Rodriguez-Sosa, Saleh, Schafer, Schindler, Shornick, Sims, Spiegel, Stein, Stolfi, Subrata, Sun, Walters, Watanabe, Wathelet, Wong, Wynn, Wynn, Y. Zhang, Yu, Zhang, Zhao, Zornetzer   +86 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Changes of vitamin D, Th17/Treg related cytokines and their correlations with disease activity in chronic spontaneous urticaria

Journal of Cutaneous Immunology and Allergy
AimsTo investigate levels of 25-hydroxyvitamin-D (25HVD), interleukin-17 (IL-17), IL-27, IL-35, and transforming growth factor β1 (TGF-β1) in chronic spontaneous urticaria (CSU) patients and their correlations with disease activity.MethodsAn ...
Yangyang Qiu, Xiaoyan Qiu, Yuting Chen, Meiqing Chen, Ling Huang, Xinyu Lin, Yi Wei, Yi Wei, Ji Yang, Ji Yang, Lujuan Gao, Lujuan Gao   +11 more
doaj   +1 more source

Interleukin-25 and Interleukin-13 Production by Alveolar Macrophages in Response to Particles [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2005
Particle inhalation-induced lung inflammation acts as an adjuvant to allergens or respiratory viral infection in a process that is mediated by macrophages and epitheliums. The production of interleukin (IL)-4 and IL-13 by activated T cells is involved in the augmentation of Th2-type immune responses to particles, and IL-25 induces the synthesis of IL-4
Chun-Mi, Kang, An-Soo, Jang, Mi-Hyun, Ahn, Jeong-Ah, Shin, Ji-Hye, Kim, Yun-Sung, Choi, Tai-Youn, Rhim, Choon-Sik, Park   +7 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Role of Interleukin-17 family cytokines in disease severity of patients with knee osteoarthritis

Advances in Rheumatology
Background Interleukin-17 (IL-17) family plays a role in the pathogenesis of knee osteoarthritis (KOA) by contributing to the inflammatory and destructive processes in the affected joint.
Zahra Kamiab, Hossein Khorramdelazad, Mehdi Kafi, Abdollah Jafarzadeh, Vahid Mohammadi-Shahrokhi, Zahra Bagheri-Hosseinabadi, Pooya Saeed Askari, Mitra Abbasifard   +7 more
doaj   +1 more source

Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis

Nature Communications, 2016
Interleukin-25 has been reported to have anticancer activity with very little effect on non-malignant cells. Here, the authors show that a synthetic phytochemical can be used to induce the secretion of Interleukin-25 from tumour associated fibroblasts ...
Shu-Yi Yin, Feng-Yin Jian, Yung-Hsiang Chen, Shih-Chang Chien, Mao-Chih Hsieh, Pei-Wen Hsiao, Wen-Hwa Lee, Yueh-Hsiung Kuo, Ning-Sun Yang   +8 more
doaj   +1 more source