Results 61 to 70 of about 4,841,277 (301)

Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps

Clinical and Translational Allergy, 2018
Background Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses.
Rui Zheng, Dan Wang, Kai Wang, Wen-Xiang Gao, Qin-Tai Yang, Li-Jie Jiang, Min Zhou, Yu-Jie Cao, Jianbo Shi, Yueqi Sun   +9 more
doaj   +1 more source

Dietary 25-Hydroxyvitamin D3 Supplementation Modulates Intestinal Cytokines in Young Broiler Chickens

Frontiers in Veterinary Science, 2022
Vitamin D signaling is important for intestinal homeostasis. An increase in vitamin D receptors in immune cells can modulate cell phenotype and cytokine secretion.
Gerardo A. Abascal-Ponciano, Samuel F. Leiva, Joshua J. Flees, Luis P. Avila, Jessica D. Starkey, Charles W. Starkey   +5 more
doaj   +1 more source

Codon optimization, expression, purification, and functional characterization of recombinant human IL-25 in Pichia pastoris [PDF]

, 2013
Interleukin (IL)-25 (also known as IL-17E) is a distinct member of the IL-17 cytokine family which induces IL-4, IL-5, and IL-13 expression and promotes pathogenic T helper (Th)-2 cell responses in various organs.
Chengsheng Wu, Jinyu Wang, Min Yu, Wei Mo, Yushan Liu   +4 more
core   +1 more source

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial

Frontiers in Immunology
BackgroundAlarmins mediate type 2 T helper cell (Th2) inflammation and serve as upstream signaling elements in allergic inflammation and autoimmune responses.
Guolin Xu, Sabina Paglialunga, Xuchen Qian, Ru Ding, Kenneth Webster, Aernout van Haarst, Caroline Engel, Chin Wai Hui, Lik Hang Lam, Weimin Li, Wai Chung Wu, Scott Rasmussen, Allen Hunt, Shui-on Leung   +13 more
doaj   +1 more source

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. [PDF]

, 2017
The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD).
Cheng, D, Di, H, Erle, DJ, Huo, X, Mo, Y, Shi, H, Xu, Y, Yi, L, Zhang, H, Zhang, K, Zhao, J, Zhen, G, Zou, Y   +12 more
core   +1 more source

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke, Edris Mohamed, Ahmed, Joos, Guy, Lahousse, Lies, Maes, Tania   +4 more
core   +1 more source

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation [PDF]

, 2014
Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure.
Andreoli, Arai, Attila Bacsi, Balmes, Caldecott, De Souza-Pinto, Hadian, Hegde, Istvan Boldogh, Koa Hosoki, Lai, Lange, Lee, Leopoldo Aguilera-Aguirre, Mabley, Mitra, Mitra, Mor, Mosteller, Muralidhar Hegde, Proklou, Qura Rashid, Sanjiv Sur, Seiler, Tang, Taylor, Xueqing Ba, Zsolt Radak   +27 more
core   +5 more sources

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation [PDF]

, 2016
Additional file 2: Table S2. Primary and secondary antibodies used during western blot analysis of lung homogenate samples. All primary antibodies were diluted in TBS-T with 5 % BSA, while the secondary antibody was diluted in TBS-T with 5 ...
Akbarshahi, Hamid,, Brandelius, Angelica,, Lund University., Mahmutovic Persson, Irma,, Menzel, Mandy,, Uller, Lena,   +5 more
core   +4 more sources

Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections

Parasites & Vectors, 2020
Background Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, which has been extensively used to investigate the factors that determine the rejection of intestinal helminths. In this sense, several studies have shown that IL-25
María Álvarez-Izquierdo, J. Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo   +3 more
doaj   +1 more source

Vitamin D attenuates cardiac hypertrophy in rats through mRNA regulation of interleukin-6 and its receptor

Research in Cardiovascular Medicine, 2023
Context: Interleukin-6 (IL-6), a pro-inflammatory cytokine, plays an important role in the pathogenesis of myocardial hypertrophy. By integrating its membrane receptor complex (gp80), IL-6 activates the signal guidance components (gp130) and activates ...
Ahad Nikkholgh, Fatemeh Tavakoli, Nasrin Alborzi, Fatemeh Araste   +3 more
doaj   +1 more source