Results 91 to 100 of about 2,200,720 (269)

Nemolizumab for the treatment of atopic dermatitis

Journal of Dermatological Treatment
Purpose Atopic dermatitis (AD) is a common, heterogeneous inflammatory skin disease characterized by chronic or relapsing eczematous lesions and intense pruritus, leading to reduced quality of life and increased mental health burden.
Erica Rodrigues, João Domingues, José Miguel Alvarenga, Raj Chovatiya, Tiago Torres   +4 more
doaj   +1 more source

Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma.

Rheumatology, 2020
OBJECTIVES Cytokines released by infiltrating T cells may promote mechanisms leading to fibrosis in scleroderma. The aim of this study was to investigate the role of the Th2 cytokine IL-31, and its receptor IL-31RA, in scleroderma skin and lung fibrosis.
Bodoor Yaseen, H. Lopez, Z. Taki, S. Zafar, H. Rosario, B. Abdi, S. Vigneswaran, F. Xing, N. Arumalla, S. Black, S. Ahmad, Kimti Kumar, Rabia Gul, Laura Scolamiero, Sian Morris, A. Bowman, Anna Stainer, A. Rice, C. Stock, E. Renzoni, C. Denton, C. Venturini, Max Brown, S. O’Reilly, R. Stratton   +24 more
semanticscholar   +1 more source

Clinical implications of interleukins-31, 32, and 33 in gastric cancer

World Journal of Gastrointestinal Oncology, 2022
Gastric cancer (GC) is one of the most common malignancies in China with a high morbidity and mortality.To determine whether interleukin (IL)-31, IL-32, and IL-33 can be used as biomarkers for the detection of GC, via evaluating the correlations between their expression and clinicopathological parameters of GC patients.Tissue array (n = 180) gastric ...
Liu, Qing-Hua, Zhang, Ji-Wei, Xia, Lei, Wise, Steven G, Hambly, Brett David, Tao, Kun, Bao, Shi-San   +6 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Biomedicines, 2020
C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction ...
Helene Hersvik Aarstad, Svein Erik Emblem Moe, Øystein Bruserud, Stein Lybak, Hans Jørgen Aarstad, Tor Henrik Anderson Tvedt   +5 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

IL-33 in Mental Disorders

Medicina, 2021
Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo, Giovanni Genovese, Marco Casciaro, Maria Rosaria Anna Muscatello, Antonio Bruno, Giovanni Pioggia, Sebastiano Gangemi   +6 more
doaj   +1 more source

Interleukin-31 expression and relation to disease severity in human asthma. [PDF]

Sci Rep, 2016
AbstractInterleukin 31 (IL-31) is a novel T helper type 2 effector cytokine that plays an important role in the pathogenesis of allergic diseases. However, its role in human asthma remains unclear. The aim of this study was to measure IL-31 levels in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of asthmatics and healthy subjects ...
Lai T, Wu D, Li W, Chen M, Yi Z, Huang D, Jing Z, Lü Y, Lv Q, Li D, Wu B.   +10 more
europepmc   +4 more sources

Minimizing conservativity violations in ontology alignments: algorithms and evaluation [PDF]

, 2017
In order to enable interoperability between ontology-based systems, ontology matching techniques have been proposed. However, when the generated mappings lead to undesired logical consequences, their usefulness may be diminished.
A Borgida, A Dovier, A Solimando, A Soylu, Alessandro Solimando, B Cuenca Grau, B Glimm, B Motik, BC Grau, C Lutz, C Lutz, C Meilicke, C Rosse, E Beisswanger, E Jiménez-Ruiz, Ernesto Jiménez-Ruiz, G Even, G Gallo, Giovanna Guerrini, J David, J Euzenat, J Euzenat, J Euzenat, J Golbeck, M Giese, M Rodriguez-Muro, O Bodenreider, P Lambrix, P Shvaiko, P Wang, R Jean-Mary Yves, R Raymond, R Tarjan, S Schulz, V Mascardi, V Nebot, WF Dowling, Y Kazakov   +37 more
core   +1 more source