Results 71 to 80 of about 56,984,652 (272)

Nemolizumab for the treatment of atopic dermatitis

Journal of Dermatological Treatment
Purpose Atopic dermatitis (AD) is a common, heterogeneous inflammatory skin disease characterized by chronic or relapsing eczematous lesions and intense pruritus, leading to reduced quality of life and increased mental health burden.
Erica Rodrigues, João Domingues, José Miguel Alvarenga, Raj Chovatiya, Tiago Torres   +4 more
doaj   +1 more source

Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice

Acta Dermato-Venereologica, 2017
A recent study suggests that interleukin-31 (IL-31) exerts its effect via indirect mechanisms rather than through direct stimulation of cutaneous nerves.
Tsugunobu Andoh, Ayako Harada, Yasushi Kuraishi   +2 more
doaj   +1 more source

Possible Role of Interleukin-31/33 Axis in Imatinib Mesylate-Associated Skin Toxicity

Turkish Journal of Hematology, 2015
Imatinib mesylate is a small-molecule tyrosine kinase inhibitor (TKi) designed to target c-ABL and BCR-ABL, approved for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors.
Caterina Musolino, Alessandro Allegra, Carmen Mannucci, Sabina Russo, Andrea Alonci, Valerio Maisano, Gioacchino Calapai, Sebastiano Gangemi   +7 more
doaj   +1 more source

Human mid-gestation amniotic fluid contains interleukin-16 bioactivity [PDF]

, 2009
CD4-positive cells are detectable in the human fetal gastrointestinal tract from 11 weeks of gestation. Interleukin-16 (IL-16) is a chemoattractant for CD4(+) cells and, via fetal swallowing of amniotic fluid, could mediate the influx of CD4(+) cells ...
Warner, J., John W. Holloway, Thornton, Catherine A., Diaper, Norma D., Holloway, John W., Diaper, N., Shute, Janis K., Warner, John O., Catherine A. Thornton, Janis K. Shute, John O. Warner, Holloway, J., Cathy Thornton, Holloway, Judith A., Shute, Jan, Norma D. Diaper, Thornton, C., Judith A. Holloway   +17 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children [PDF]

Korean Journal of Pediatrics, 2015
PurposeAtopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD.
Bo Ram Cheon, Jeong Eun Shin, Yun Ji Kim, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim   +7 more
doaj   +1 more source

Interleukin-31 expression and relation to disease severity in human asthma. [PDF]

Sci Rep, 2016
AbstractInterleukin 31 (IL-31) is a novel T helper type 2 effector cytokine that plays an important role in the pathogenesis of allergic diseases. However, its role in human asthma remains unclear. The aim of this study was to measure IL-31 levels in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of asthmatics and healthy subjects ...
Lai T, Wu D, Li W, Chen M, Yi Z, Huang D, Jing Z, Lü Y, Lv Q, Li D, Wu B.   +10 more
europepmc   +4 more sources

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes:the MRC-ILA Heart Study [PDF]

, 2014
AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation.
Greenwood, J.P., Hall, Alistair S., Rothman, A.M.K., Morton, Allison C., Foley, C., Chase, A., Greenwood, John P, Chase, Alex, Morton, Allison C, Wang, Duolao, Rothman, Alexander M K, Banya, Winston, Clarke, B., Gunn, J., Crossman, David C, Rothman, Alexander M. K., Crossman, David C., Flather, Marcus D, Rothman, Alexander M.K., Clarke, Bernard, Fox, Keith, Fox, K., Banya, W., Hall, Alistair S, Gunn, Julian, Flather, Marcus D., Greenwood, John P., Foley, Claire, Hall, A.S., Morton, A.C., Crossman, David C; id_orcid   +30 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

FLOCK -flare clock: Passive sweat-based eczematous flare detection system

Biosensors and Bioelectronics: X, 2022
FLOCK (flare clock) system is a novel platform that comprises of a nanoporous membrane based multilayer stack that works with passively secreted sweat. It is designed to capture eczema severity and circadian disruption caused due to its symptoms. This is
Sayali Upasham, Paul Rice, Madhavi Pali, Shalini Prasad   +3 more
doaj   +1 more source