Results 21 to 30 of about 2,108,740 (316)

Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis

Frontiers in Immunology, 2018
Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory
Liya Li, Liya Li, Honglin Zhu, Honglin Zhu, Xiaoxia Zuo, Xiaoxia Zuo   +5 more
doaj   +3 more sources

Interleukin 33: a suitable target for biological therapies of COPD? [PDF]

ERJ Open Research
Corrado Pelaia
doaj   +2 more sources

Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD

European Respiratory Review, 2023
Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are released upon airway epithelial injury from insults such as viruses and cigarette smoke, and play critical roles in the activation of immune cell populations such as ...
Ariel A. Calderon, Colin Dimond, D. Choy, R. Pappu, M. Grimbaldeston, Divya Mohan, K. Chung   +6 more
semanticscholar   +1 more source

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine.

Cytokine, 2022
Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.
C. Cayrol, J. Girard
semanticscholar   +1 more source

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.

Immunity, 2023
T cell factor 1 (Tcf-1) expressing CD8+ T cells exhibit stem-like self-renewing capacity, rendering them key for immune defense against chronic viral infection and cancer. Yet, the signals that promote the formation and maintenance of these stem-like CD8+
Anna-Friederike Marx, S. Kallert, Tobias M. Brunner, José A. Villegas, F. Geier, Jonas Fixemer, Tiago Abreu-Mota, P. Reuther, Weldy V. Bonilla, Jelizaveta Fadejeva, M. Kreutzfeldt, Ingrid Wagner, Patricia Aparicio-Domingo, L. Scarpellino, M. Charmoy, Daniel T. Utzschneider, C. Hagedorn, Min Lu, K. Cornille, K. Stauffer, F. Kreppel, D. Merkler, D. Zehn, W. Held, S. Luther, M. Löhning, D. Pinschewer   +26 more
semanticscholar   +1 more source

Exogenous interleukin 33 enhances the brain’s lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice

Acta Neuropathologica Communications, 2023
The persistent dysregulation and accumulation of poisonous proteins from destructive neural tissues and cells activate pathological mechanisms after traumatic brain injury (TBI).
Mingqi Liu, Jinhao Huang, T. Liu, Jiangyuan Yuan, Chuanxiang Lv, Z. Sha, Chenrui Wu, Weiwei Jiang, Xuanhui Liu, Meng Nie, Yupeng Chen, S. Dong, Yu Qian, Chuang Gao, Yibing Fan, Di Wu, Rongcai Jiang   +16 more
semanticscholar   +1 more source

Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes

Circulation, 2023
Background: Acute kidney injury (AKI) is a short-term life-threatening condition that, if survived, can lead to renal insufficiency and development of chronic kidney disease.
Nans Florens, Rajesh K. Kasam, Valeria Rudman-Melnick, Suh-Chin J. Lin, V. Prasad, J. Molkentin   +5 more
semanticscholar   +1 more source

Interleukin‐33 in allergy [PDF]

Allergy, 2012
AbstractInterleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1 and IL‐18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL‐33 receptor. IL‐33 receptor is a heterodimer of IL‐1 receptor‐like 1 (IL‐1RL1; also called ST2, T1, Der4, and fit‐1) and IL‐1 receptor ...
Tatsukuni, Ohno, Hideaki, Morita, Ken, Arae, Kenji, Matsumoto, Susumu, Nakae   +4 more
openaire   +2 more sources

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

Journal of Translational Medicine, 2022
With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological diseases with cognitive dysfunction such as ...
Xiuqin Rao, Fuzhou Hua, Lieliang Zhang, Yue-Jun Lin, Pu Fang, Shoulin Chen, Jun Ying, Xifeng Wang   +7 more
semanticscholar   +1 more source

Signaling and functions of interleukin-33 in immune regulation and diseases

Cell Insight, 2022
Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy and type 2 immunity. IL-33 transmits signals through its receptor IL-33R
Xue-Mei Yi, Huan Lian, Shu Li
semanticscholar   +1 more source