Results 21 to 30 of about 434,636 (318)

Interleukin‐33 in allergy [PDF]

Allergy, 2012
AbstractInterleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1 and IL‐18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL‐33 receptor. IL‐33 receptor is a heterodimer of IL‐1 receptor‐like 1 (IL‐1RL1; also called ST2, T1, Der4, and fit‐1) and IL‐1 receptor ...
Tatsukuni, Ohno, Hideaki, Morita, Ken, Arae, Kenji, Matsumoto, Susumu, Nakae   +4 more
openaire   +2 more sources

Interleukin-33 links asthma to alopecia areata: Mendelian randomization and mediation analysis. [PDF]

Skin Res Technol
Wu P, Tian K, Gao S, Jia Z, Xu W, Wang X, Wu L.   +6 more
europepmc   +2 more sources

Interleukin-33 in the human placenta [PDF]

The Journal of Maternal-Fetal & Neonatal Medicine, 2012
Interleukin-33 (IL-33) is the newest member of the IL-1 cytokine family, a group of key regulators of inflammation. The purpose of this study was to determine whether IL-33 is expressed in the human placenta and to investigate its expression in the context of acute and chronic chorioamnionitis.Placental tissues were obtained from five groups of ...
Vanessa, Topping, Roberto, Romero, Nandor Gabor, Than, Adi L, Tarca, Zhonghui, Xu, Sun Young, Kim, Bing, Wang, Lami, Yeo, Chong Jai, Kim, Sonia S, Hassan, Jung-Sun, Kim   +10 more
openaire   +2 more sources

Interleukin-33 modulates inflammation in endometriosis [PDF]

Scientific Reports, 2017
AbstractEndometriosis is a debilitating condition that is categorized by the abnormal growth of endometrial tissue outside the uterus. Although the pathogenesis of this disease remains unknown, it is well established that endometriosis patients exhibit immune dysfunction.
Miller, Jessica E., Monsanto, Stephany P., Ahn, Soo Hyun, Khalaj, Kasra, Fazleabas, Asgerally T., Young, Steven L., Lessey, Bruce A., Koti, Madhuri, Tayade, Chandrakant   +8 more
openaire   +2 more sources

Interleukin 33: a switch-hitting cytokine [PDF]

Current Opinion in Immunology, 2014
For many years IL-33 has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote Th2 immunity, but also to induce T helper type 1 (Th1 ...
Daniel O, Villarreal, David B, Weiner
openaire   +2 more sources

Behavioral Changes in Mice Lacking Interleukin-33 [PDF]

eneuro, 2017
AbstractInterleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is expressed in nuclei and secreted as alarmin upon cellular damage to deliver a danger signal to the surrounding cells. Previous studies showed that IL-33 is expressed in the brain and that it is involved in neuroinflammatory and neurodegenerative processes in both humans ...
Eisuke Dohi, Eric Y. Choi, Indigo V.L. Rose, Akiho S. Murata, Sharon Chow, Minae Niwa, Shin-ichi Kano   +6 more
openaire   +2 more sources

Replicating viral vector platform exploits alarmin signals for potent CD8⁺ T cell-mediated tumour immunotherapy. [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL ^eff ) responses. Conversely, the induction of protective tumour-specific CTL ^eff and their recruitment into the
A Hyvarinen, A Plyusnin, A Wortmann, AM Henao-Restrepo, C Baumann, C Butts, CA Klebanoff, CB Stephensen, D Peng, D Valmori, D Zamarin, DA Enria, DK Reichenbach, DL Popkin, E Scandella, ER Chare, F Duan, F Pages, F Spertini, GP Dunn, HE Webb, J Delaloye, J Liu, J Zhu, JA Joyce, JF Vansteenkiste, JY Liu, K Oboki, KM Quinn, L Flatz, L Flatz, L Flatz, L Zhang, LC Anton, M Lewandoski, M Peine, M Perez, M Suter, M Vanneman, MD Stenglein, MF Callan, MF Kotturi, MJ Townsend, N Fasnacht, O Kew, P Grob, P Sharma, PC Doherty, PC Tumeh, PW Kantoff, R Schirmbeck, R Sommerstein, RH Andtbacka, RM Zinkernagel, RM Zinkernagel, S Darbre, S Spranger, SA Fuertes Marraco, SA Rosenberg, SF Emonet, SG Hansen, SN Mueller, T Querec, TF Gajewski, TN Schumacher, WV Bonilla, WV Bonilla, X de Lamballerie, Y Iwai, Z Waibler   +69 more
core   +2 more sources

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation [PDF]

Immunity, 2015
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is highly expressed on group 2 innate lymphoid cells (ILC2s) and T helper 2 (Th2) cells, thus underpinning its association with helminth infection and allergic ...
Ari B. Molofsky, Adam K. Savage, Richard M. Locksley   +2 more
openalex   +5 more sources

IL-33 in Mental Disorders

Medicina, 2021
Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo, Giovanni Genovese, Marco Casciaro, Maria Rosaria Anna Muscatello, Antonio Bruno, Giovanni Pioggia, Sebastiano Gangemi   +6 more
doaj   +1 more source

The role of interleukin-33 in organ fibrosis. [PDF]

Discov Immunol, 2022
Summary Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via the ST2 receptor. IL-33 signalling via ST2 is essential for return to tissue homeostasis after acute inflammation, promoting fibrinogenesis and wound healing at injury sites.
Di Carmine S, Scott MM, McLean MH, McSorley HJ.   +3 more
europepmc   +4 more sources