Results 31 to 40 of about 2,108,740 (316)
Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions
Cells, 2022 Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine, plays critical roles in maintaining host homeostasis and in pathological conditions, such as allergy, infectious diseases, and cancer, by acting on multiple ...
Hang Guo +4 more
semanticscholar +1 more source
Stroke, 2021 Supplemental Digital Content is available in the text. Background and Purpose: Emerging evidence highlights the importance of IL33 (interleukin 33) and its receptor (ST2 [interleukin 1 receptor-like 1]) in normal brains and neurological disorders.
Di Xie +8 more
semanticscholar +1 more source
Interleukin-33 in the human placenta [PDF]
The Journal of Maternal-Fetal & Neonatal Medicine, 2012 Interleukin-33 (IL-33) is the newest member of the IL-1 cytokine family, a group of key regulators of inflammation. The purpose of this study was to determine whether IL-33 is expressed in the human placenta and to investigate its expression in the context of acute and chronic chorioamnionitis.Placental tissues were obtained from five groups of ...
Vanessa, Topping +10 more
openaire +2 more sources
Therapeutic Opportunities of Interleukin-33 in the Central Nervous System
Frontiers in Immunology, 2021 Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is involved in various diseases. IL-33 exerts its effects via its heterodimeric receptor complex, which comprises suppression of tumorigenicity 2 (ST2) and the IL-1 receptor accessory protein (
Yun Sun +9 more
semanticscholar +1 more source
Interleukin-33 modulates inflammation in endometriosis [PDF]
Scientific Reports, 2017 AbstractEndometriosis is a debilitating condition that is categorized by the abnormal growth of endometrial tissue outside the uterus. Although the pathogenesis of this disease remains unknown, it is well established that endometriosis patients exhibit immune dysfunction.
Miller, Jessica E. +8 more
openaire +2 more sources
Interleukin 33: a switch-hitting cytokine [PDF]
Current Opinion in Immunology, 2014 For many years IL-33 has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote Th2 immunity, but also to induce T helper type 1 (Th1 ...
Daniel O, Villarreal, David B, Weiner
openaire +2 more sources
Behavioral Changes in Mice Lacking Interleukin-33 [PDF]
eneuro, 2017 AbstractInterleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is expressed in nuclei and secreted as alarmin upon cellular damage to deliver a danger signal to the surrounding cells. Previous studies showed that IL-33 is expressed in the brain and that it is involved in neuroinflammatory and neurodegenerative processes in both humans ...
Eisuke Dohi +6 more
openaire +2 more sources
Advancement of science, 2021 Recognition of specific antigens expressed in cancer cells is the initial process of cytolytic T cell‐mediated cancer killing. However, this process can be affected by other non‐cancerous cellular components in the tumor microenvironment.
Jing Wu +18 more
semanticscholar +1 more source
Interleukin‐33 (IL‐33): A nuclear cytokine from the IL‐1 family
Immunological Reviews, 2018 Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both during homeostasis and inflammation.
C. Cayrol, J. Girard
semanticscholar +1 more source
Pathophysiologic role of Interleukin-33/ST2 in Sjögren's syndrome.
Autoimmunity Reviews, 2021 Interleukin-33 (IL-33) is a member of the IL-1 family and has dual functions as a nuclear factor as well as a cytokine. The pivotal role of IL-33 as an active player contributing to aberrant local and systemic damage has been highlighted in several ...
M. Shanawaz, C. Nicaise
semanticscholar +1 more source