Results 151 to 160 of about 2,709,028 (238)

Interleukin-35 -producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification. [PDF]

Cell Death Discov, 2023
Xie M, Zhu Y, Zhou Y, Wang Q, Gu E, Chu Y, Wang L.   +6 more
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Serum Interleukin-35 Levels in Oral Squamous Cell Carcinoma and Salivary Gland Tumors: Implications for Early Detection and Prognosis. [PDF]

Biomed Res Int
Zahed M, Maroofi S, Ghapanchi J, Khademi B, Ghaderi A, Fattahi MJ, Hayati N, Khoubani F.   +7 more
europepmc   +1 more source

Elevated levels of interleukin-35 and interleukin-37 in adult patients with obstructive sleep apnea. [PDF]

J Clin Lab Anal, 2021
Chen B, Liu YN, Ji L, Liu PL, He J, Gan YY, Ji GJ, Zhu SY, Zhang WH.   +8 more
europepmc   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Tumor-Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells. [PDF]

Adv Sci (Weinh)
Li H, Sun H, Liu J, Wu Y, Wei L, Li J, Yuan Y, Xie P, Xu C, Luo G, Guan Y, Feng Y, Chang A, Hao J, Huang C.   +14 more
europepmc   +1 more source

Elevated Plasma Interleukin-35 as a Prognostic Indicator in Localized Clear Cell Renal Cell Carcinoma.

Evid Based Complement Alternat Med, 2022
Zhang J, Xu X, Chen Z, Zhu Z, Hou J.
europepmc   +1 more source

Interleukin-35 promotes Breg expansion and interleukin-10 production in CD19⁺ B cells in patients with ankylosing spondylitis. [PDF]

Clin Rheumatol, 2022
Zhang Y, Wei S, Wu Q, Shen X, Dai W, Zhang Z, Chen M, Huang H, Ma L.   +8 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Interleukin-35 exhibits protective effects in a rat model of hypoxic-ischemic encephalopathy through the inhibition of microglia-mediated inflammation. [PDF]

Transl Pediatr, 2022
Liu G, Li M, Qian S, Yu L, Qian L, Feng X.   +5 more
europepmc   +1 more source