Results 1 to 10 of about 393,705 (229)

Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes. [PDF]

PLoS ONE, 2019
Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Dominique Talabot-Ayer, Loïc Mermoud, Julia Borowczyk, Justyna Drukala, Michal Wolnicki, Ali Modarressi, Wolf-Henning Boehncke, Nicolo Brembilla, Gaby Palmer   +8 more
doaj   +8 more sources

Circulating interleukin-38 concentrations in healthy adults [PDF]

Frontiers in Immunology, 2022
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize its ...
Lisa U. Teufel, Dennis M. de Graaf, Dennis M. de Graaf, Dennis M. de Graaf, Mihai G. Netea, Mihai G. Netea, Charles A. Dinarello, Charles A. Dinarello, Leo A. B. Joosten, Leo A. B. Joosten, Rob J. W. Arts   +10 more
doaj   +6 more sources

Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients [PDF]

Immunity, Inflammation and Disease, 2022
Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory properties, but thus far ...
Dennis M. deGraaf, Lisa U. Teufel, Aline H. deNooijer, Adriaan J. vanGammeren, Antonius A. M. Ermens, Ildikó O. Gaál, Tania O. Crișan, Frank L. van deVeerdonk, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts, the Radboudumc Center for Infectious Diseases COVID‐19 Study Group   +12 more
doaj   +6 more sources

Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3 [PDF]

Proceedings of the National Academy of Sciences, 2022
Calcific aortic valve disease (CAVD) is common in people over the age of 65. Progressive valvular calcification is a characteristic of CAVD and due to chronic inflammation in aortic valve interstitial cells (AVICs) resulting in CAVD progression. IL-38 is a naturally occurring anti-inflammatory cytokine; here, we report lower levels of endogenous IL-38 ...
Erlinda The, Dennis M. de Graaf, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Charles A. Dinarello, Xianzhong Meng   +7 more
europepmc   +5 more sources

Interleukin-38 and cardiovascular pathology: literature review [PDF]

КардиоСоматика, 2023
Cardiovascular pathology is a leading cause of morbidity and mortality. An important task of modern cardiology is the search and study of new biological markers. Scientists’ interest is actively focused on the study of interleukin-38.
Amina M. Alieva, Irina E. Baykova, Tatyana V. Pinchuk, Irina A. Kotikova, Igor G. Nikitin   +4 more
doaj   +4 more sources

Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice [PDF]

Frontiers in Immunology
Psoriasis is a common chronic inflammatory skin disease that significantly impacts the patients’ quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family member IL-38 in skin homeostasis and suggested an anti-inflammatory
Arnaud Huard, Arnaud Huard, Arnaud Huard, Emiliana Rodriguez, Emiliana Rodriguez, Emiliana Rodriguez, Dominique Talabot-Ayer, Dominique Talabot-Ayer, Dominique Talabot-Ayer, Andreas Weigert, Gaby Palmer, Gaby Palmer, Gaby Palmer   +12 more
doaj   +3 more sources

Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis [PDF]

Journal of Clinical Laboratory Analysis, 2021
AbstractBackgroundAutoimmune thyroid disease (AITD) mainly includes Graves’ disease (GD) and Hashimoto's thyroiditis (HT), which is caused by individual genetics, autoimmune dysfunction, and a variety of external environmental factors. Interleukin (IL)‐38 is involved in a wide range of autoimmune diseases, but little is known about IL‐38 expression in ...
Jialu Xu, Guoqing Huang, Linjie Weng, Luping Gong, Yushan Mao, Yan Li, Mingcai Li   +6 more
europepmc   +4 more sources

Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors [PDF]

Cell Communication and Signaling
Background Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer   +8 more
doaj   +3 more sources

Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression [PDF]

Open Biology, 2018
Lung cancer continues to be the leading cause of cancer-related deaths worldwide due to its high incidence, malignant behaviour and lack of major advancements in treatment strategy.
Feng Wang, Weihua Zhang, Tianfeng Wu, Heying Chu   +3 more
doaj   +3 more sources

Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner [PDF]

Physiological Reports, 2023
Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi   +7 more
doaj   +3 more sources