Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review [PDF]
Frontiers in Immunology, 2018 Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta,
Wang-Dong Xu, A. Huang
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Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice [PDF]
Frontiers in ImmunologyPsoriasis is a common chronic inflammatory skin disease that significantly impacts the patients’ quality of life. Recent studies highlighted the function of the interleukin (IL)-1 family member IL-38 in skin homeostasis and suggested an anti-inflammatory
Arnaud Huard +4 more
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors [PDF]
Cell Communication and SignalingBackground Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Díaz-Barreiro +8 more
doaj +5 more sources
Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3 [PDF]
Proceedings of the National Academy of Sciences, 2022 Significance Calcific aortic valve disease (CAVD) is a common aging-related cardiovascular disease with no pharmacological therapy presently. CAVD pathobiology has chronic inflammation and progressive calcification in aortic valve leaflets. We found that
Erlinda The +7 more
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Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis [PDF]
Journal of Clinical Laboratory Analysis, 2021 Autoimmune thyroid disease (AITD) mainly includes Graves’ disease (GD) and Hashimoto's thyroiditis (HT), which is caused by individual genetics, autoimmune dysfunction, and a variety of external environmental factors. Interleukin (IL)‐38 is involved in a
Jialu Xu +6 more
semanticscholar +7 more sources
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections [PDF]
Cell Death and Disease, 2021 Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown.
Xun Gao +9 more
semanticscholar +4 more sources
Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with various AF prognostic factors in a cohort study and assessed their predictive value for the ...
Jiaxue Ma +8 more
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Interleukin‐38 alleviates cardiac remodelling after myocardial infarction [PDF]
Journal of Cellular and Molecular Medicine, 2019 Excessive immune‐mediated inflammatory reaction plays a deleterious role in ventricular remodelling after myocardial infarction (MI). Interleukin (IL)‐38 is a newly characterized cytokine of the IL‐1 family and has been reported to exert a protective ...
Yuzhen Wei +9 more
semanticscholar +6 more sources
The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease [PDF]
Journal of Clinical Biochemistry and Nutrition, 2021 Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and ...
Masashi Ohno +7 more
semanticscholar +7 more sources
The decreased serum levels of interleukin-38 in patients with gout and its clinical significance [PDF]
Frontiers in ImmunologyBackgroundInterleukin (IL)-38 is a newly discovered anti-inflammatory cytokine. However, its concentration and clinical significance in patients with gout remain unclear. This study aimed to investigate the levels of IL-38 in patients with gout and evaluate their clinical significance.MethodsThirty-two patients with active gout, 27 patients with ...
Hua Huang +5 more
doaj +6 more sources