Interleukin-38 promoter variants and risk of COVID-19 among Iraqis [PDF]
Immunobiology, 2022 Coronavirus disease-19 (COVID-19) has recently emerged as a respiratory infection with a significant impact on health and society. The pathogenesis is primarily attributed to a dysregulation of cytokines, especially those with pro-inflammatory and anti-inflammatory effects. Interleukin-38 (IL-38) is a recently identified anti-inflammatory cytokine with
Al-Karaawi, Ibtihal A. +3 more
europepmc +5 more sources
Neutralization of interleukin-38 exacerbates coxsackievirus B3-induced acute myocarditis in mice [PDF]
Virology Journal, 2021 Background Interleukin (IL)-38, a novel member of the IL-1 family, has been reported to be involved in several diseases associated with viral infection. However, the expression and functional role of IL-38 in acute viral myocarditis (AVMC) have not been ...
Yimin Xue +7 more
doaj +4 more sources
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections [PDF]
Cell Death and Disease, 2021 Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown.
Xun Gao +9 more
doaj +3 more sources
Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with
Jiaxue Ma +13 more
doaj +3 more sources
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy [PDF]
Scientific Reports, 2017 Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown.
Jing Zhang +9 more
doaj +5 more sources
Interleukin‐38 alleviates cardiac remodelling after myocardial infarction [PDF]
Journal of Cellular and Molecular Medicine, 2019 AbstractExcessive immune‐mediated inflammatory reaction plays a deleterious role in ventricular remodelling after myocardial infarction (MI). Interleukin (IL)‐38 is a newly characterized cytokine of the IL‐1 family and has been reported to exert a protective effect in some autoimmune diseases.
Yuzhen Wei +9 more
europepmc +4 more sources
Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review [PDF]
Frontiers in Immunology, 2018 Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta,
Wang-Dong Xu, An-Fang Huang
doaj +4 more sources
Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]
iScienceSummary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Lisa U. Teufel +12 more
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Indian Journal of DermatologyBackground: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases.
Alper Ekinci +3 more
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Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma [PDF]
Cellular & Molecular Immunology, 2019 Abstract We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce expression of cytokines/chemokines/adhesion molecules.
Xiaoyu Sun +9 more
europepmc +4 more sources