Indian Journal of DermatologyAbstract Background: Rosacea is a chronic inflammatory skin disease. Previous studies have determined that IL-36, IL-37, and IL-38 may play a role in the pathogenesis of various inflammatory diseases. Aims and Objectives: The present study aims to evaluate the relationship
Alper Ekinci +3 more
doaj +8 more sources
Reduced interleukin-38 in non-small cell lung cancer is associated with tumour progression [PDF]
Open Biology, 2018 Lung cancer continues to be the leading cause of cancer-related deaths worldwide due to its high incidence, malignant behaviour and lack of major advancements in treatment strategy.
Feng Wang +3 more
semanticscholar +9 more sources
Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity [PDF]
International Journal of Molecular Sciences, 2023 Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immunity
Lisa U. Teufel +5 more
semanticscholar +5 more sources
Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner [PDF]
Physiological Reports, 2023 Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐
Shun Kurose +7 more
semanticscholar +3 more sources
Evaluation of interleukin‐38 levels in serum of patients with coronavirus disease 2019 [PDF]
Journal of Medical Virology, 2022 Interleukin‐38 (IL‐38) has recently been considered as a cytokine with anti‐inflammatory properties in viral respiratory infections, particularly coronavirus disease 19 (COVID‐19), but the evidence has not been well elucidated.
Wasan W. Al-bassam +3 more
semanticscholar +4 more sources
Interleukin‐38 protects against sepsis by augmenting immunosuppressive activity of CD4+CD25+ regulatory T cells [PDF]
J Cell Mol Med, 2019 Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are required to limit immune‐induced pathology and to maintain homeostasis during the early‐phase of sepsis.
Yun Ge +4 more
semanticscholar +3 more sources
Iranian Journal of Allergy, Asthma and Immunology, 2021 Evidence showed that chronic inflammatory and immunopathological responses play a pivotal role in the development of osteoarthritis (OA). Interleukin-38 (IL-38) as a novel anti-inflammatory cytokine with influential modulatory properties on both innate ...
Mitra Abassifard +3 more
semanticscholar +4 more sources
Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. And it is tightly related to chronic inflammation. Interleukin-38 (IL-38) represents a new member of anti-inflammatory cytokines.
N. Yang +6 more
semanticscholar +5 more sources
Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma [PDF]
Cellular & Molecular Immunology, 2019 We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce ...
Xiaoyu Sun +9 more
semanticscholar +4 more sources
Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses [PDF]
Journal of Molecular Cell Biology, 2016 Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic) cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) family cytokines are key players in this interaction.
Javier Mora +10 more
semanticscholar +5 more sources