The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease [PDF]
Journal of Clinical Biochemistry and Nutrition, 2022 Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions.
Ohno, Masashi +7 more
europepmc +5 more sources
Serum interleukin 38 (IL-38) as a new potential biomarker of pediatric asthma [PDF]
The Egyptian Journal of Bronchology, 2022 Background Bronchial asthma is considered the most prevalent chronic respiratory disease worldwide and is one of the main causes of hospitalization in the pediatric population.
Asmaa Kamal +3 more
doaj +2 more sources
Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity [PDF]
International Journal of Molecular Sciences, 2023 Trained immunity is the process of long-term functional reprogramming (a de facto innate immune memory) of innate immune cells such as monocytes and macrophages after an exposure to pathogens, vaccines, or their ligands. The induction of trained immunity is mediated through epigenetic and metabolic mechanisms.
Lisa U. Teufel +5 more
openaire +4 more sources
Interleukin-38 in Health and Disease [PDF]
Cytokine, 2022 Contains fulltext : 252005.pdf (Publisher’s version ) (Open Access)
Graaf, D.M. de +3 more
openaire +4 more sources
Interleukin‐38 promotes skin tumorigenesis in an IL‐1Rrp2‐dependent manner [PDF]
EMBO reports, 2022 Interleukin-38 (IL-38) is strongly associated with chronic inflammatory diseases; however, its role in tumorigenesis is poorly understood. We demonstrated that expression of IL-38, which exhibits high expression in the skin, is downregulated in human cutaneous squamous cell carcinoma and 7,12-dimethylbenzanthracene/12-O-tetradecanoyl phorbol-13-acetate-
Hong Zhou +24 more
openaire +3 more sources
Interleukin 38 Protects Against Lethal Sepsis [PDF]
The Journal of Infectious Diseases, 2018 Interleukin 38 (IL-38) is the most recently characterized cytokine of the interleukin 1 family. However, its role in sepsis remains unknown.Circulating IL-38 levels were measured in 2 cohorts of adult and pediatric patients with sepsis. Using 2 murine models of lipopolysaccharide (LPS)-induced endotoxemia and cecal ligation and puncture (CLP)-induced ...
Fang, Xu +6 more
openaire +3 more sources
Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. And it is tightly related to chronic inflammation. Interleukin-38 (IL-38) represents a new member of anti-inflammatory cytokines.
Ning Yang +6 more
doaj +2 more sources
Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis [PDF]
BiomoleculesObjectives: As a novel member of the interleukin(IL)-1 family, IL-38 has shown therapeutic effects in various chronic inflammatory diseases. However, its role and underlying mechanisms in cardiovascular diseases, particularly atherosclerosis, remain ...
Zhiyang Li +9 more
doaj +2 more sources
The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications [PDF]
Frontiers in ImmunologyAutism spectrum disorder (ASD) is a complicated neurodevelopmental syndrome characterized by abnormalities in social communication, lack of interests, and repetitive behaviors.
Zakeya Al Rasbi +7 more
doaj +2 more sources
Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses [PDF]
Journal of Molecular Cell Biology, 2016 Different modes of cell death regulate immunity. Whereas necrotic (necroptotic, pyroptotic) cell death triggers inflammation, apoptosis contributes to its resolution. Interleukin-1 (IL-1) family cytokines are key players in this interaction. A number of IL-1 family cytokines are produced by necrotic cells to induce sterile inflammation.
Javier, Mora +10 more
openaire +3 more sources