Results 21 to 30 of about 12,582,645 (332)

The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling

Oncogenesis, 2017
Interleukin-4 plays a critical role in the regulation of immune responses and has been detected at high levels in the tumour microenvironment of cancer patients, where concentrations correlate with the grade of malignancy. In prostate cancer, interleukin-
G. Nappo, F. Handle, F. Santer, R. McNeill, Robert I Seed, A. Collins, G. Morrone, Z. Culig, N. Maitland, H. Erb   +9 more
semanticscholar   +1 more source

Lack of association between interleukin 13, interleukin 4 receptor alpha, andMS4A2 gene polymorphisms and asthma in adult Saudis

Journal of Nature and Science of Medicine, 2020
Objectives: Several genes, including interleukin-13 (IL13), MS4A2, and IL 4 receptor alpha (IL4Rα), have been shown to associate with the inflammatory process in asthma.
Eman A Al Abdulsalam, Mohamed S Al-Hajjaj, Mohammad S Alanazi, Arjumand S Warsy   +3 more
doaj   +1 more source

Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells

Frontiers in Immunology, 2017
Interleukin-4 (IL-4) has been considered as one of the tolerogenic cytokines in many autoimmune animal models and clinical settings. Despite its role in antagonizing pathogenic Th1 responses, little is known about whether IL-4 possesses functions that ...
Wei-Cheng Yang, Y. Hwang, Ying-Yu Chen, Chao-Lin Liu, Chia-Ning Shen, Wei-Hsin Hong, Sheng-Min Lo, Chia-Rui Shen   +7 more
semanticscholar   +1 more source

Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α [PDF]

Avicenna Journal of Phytomedicine
Objective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal ...
Hesamodin Bagheripoor, Mahdieh Mondanizadeh, Mehdi Sadegh   +2 more
doaj   +1 more source

Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells

Central European Journal of Immunology, 2019
Cytokines are signalling proteins generated in most part by immune cells that have critical functions in cellular lifespan. Here we present recent data on three selected anti-inflammatory cytokines: interleukin (IL)-10, IL-4 and transforming growth ...
Konrad Kwaśniak, Justyna Czarnik-Kwaśniak, Aleksandra Maziarz, David Aebisher, Kinga Zielińska, Bożenna Karczmarek-Borowska, Jacek Tabarkiewicz   +6 more
doaj   +1 more source

IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View

Frontiers in Immunology, 2018
In this historical perspective, written in honor of Dr. William E. Paul, we describe the initial discovery of one of the dominant substrates for tyrosine phosphorylation stimulated by IL-4.
Achsah D. Keegan, Achsah D. Keegan, Jose Zamorano, Aleksander Keselman, Nicola M. Heller   +4 more
doaj   +1 more source

In search of biomarkers for low back pain: can traction therapy effectiveness be prognosed by surface electromyography or blood parameters?

Frontiers in Physiology, 2023
Background: Lumbar traction therapy is a common method to reduce low back pain (LBP) but is not always effective. The search for biomarkers that would prognose the effectiveness of LBP management is one priority for improving patients’ quality of life ...
Marzena Ratajczak, Małgorzata Waszak, Ewa Śliwicka, Michał Wendt, Damian Skrypnik, Jacek Zieliński, Piotr Krutki   +6 more
doaj   +1 more source

Wikstroemiaganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice

Molecules, 2021
Plants of the genus Wikstroemia are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether Wikstroemia ganpi (Siebold and Zucc.) Maxim. offers
Jonghwan Jegal, No-June Park, Beom-Geun Jo, Tae-Young Kim, Sim-Kyu Bong, Sangho Choi, Jin-Hyub Paik, Jung-Won Kim, Su-Nam Kim, Min Hye Yang   +9 more
doaj   +1 more source

Content of Pro- and Anti-inflammatory Cytokines in Blood Serum of Children with Bronchial Asthma of Various Severity

Zdorovʹe Rebenka, 2012
The paper presents the findings of investigation of content of proinflammatory interleukin-1 and anti-inflammatory interleukin-4 in blood serum of children with asthma in the dynamics of disease and dependence of their level on severity of illness ...
O.I. Smiyan, V.O. Kurganska, O.P. Moshchych, P.I. Sichnenko, V.A. Gorbas   +4 more
doaj   +1 more source

Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis [PDF]

Osteoarthritis and Cartilage, 2010
IL-13/IL-4/IL-4R system has strong chondroprotective activity. We investigated polymorphisms in these genes as potential hand osteoarthritis (OA) susceptibility loci by performing a case-control association study.Eighteen common single nucleotide polymorphisms (SNPs) (nine in IL-4R, five in IL-4 and four in IL-13) were genotyped in 403 patients (380 ...
Vargiolu M., Silvestri T., BONORA, ELENA, Dolzani P., Pulsatelli L., ADDIMANDA, OLGA, Mancarella L., Punzi L., Fioravanti A., FACCHINI, ANDREA, ROMEO, GIOVANNI, MELICONI, RICCARDO   +11 more
openaire   +4 more sources