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Advanced Science, EarlyView.Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang +9 more
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Advances in Neuroimmunology, 1992
Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils.
A N, McKenzie, C J, Sanderson
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Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils.
A N, McKenzie, C J, Sanderson
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Interleukin 5 and its receptor
Progress in Growth Factor Research, 1991IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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Interleukin‐5 in eosinophilic gastroenteritis
American Journal of Hematology, 1992AbstractDuring a 4‐year period a 28‐year‐old female had 4 episodes of eosinophilia of over 10,000/μ1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils.
T, Takahashi +8 more
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Interleukin-5 and Human B Lymphocytes
Methods, 1997Interleukin-5 was initially characterized in murine systems, where it was found to have B-lymphocyte proliferative and differentiative activity and to promote the growth of eosinophils. Recombinant production of human IL-5 was soon accomplished by using murine IL-5 cDNA to isolate the highly homologous human sequence. Although human IL-5 was also found
M A, Baumann, C C, Paul
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1995
Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin 5 and B cell differentiation
Cytokine & Growth Factor Reviews, 1998Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells and eosinophils. IL-5 receptor (IL-5R) comprises alpha and (beta)c chains. IL-5 specifically binds to IL-5Ralpha and induces the recruitment of (beta)c to IL-5Ralpha. JAK2 and JAK1 tyrosine kinases are constitutively associated with hIL-5Ralpha and (beta)c, respectively and ...
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