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Advances in Neuroimmunology, 1992
Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils.
A N, McKenzie, C J, Sanderson
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Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils.
A N, McKenzie, C J, Sanderson
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Interleukin 5 and its receptor
Progress in Growth Factor Research, 1991IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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Interleukin‐5 in eosinophilic gastroenteritis
American Journal of Hematology, 1992AbstractDuring a 4‐year period a 28‐year‐old female had 4 episodes of eosinophilia of over 10,000/μ1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils.
T, Takahashi +8 more
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Interleukin-5 and Human B Lymphocytes
Methods, 1997Interleukin-5 was initially characterized in murine systems, where it was found to have B-lymphocyte proliferative and differentiative activity and to promote the growth of eosinophils. Recombinant production of human IL-5 was soon accomplished by using murine IL-5 cDNA to isolate the highly homologous human sequence. Although human IL-5 was also found
M A, Baumann, C C, Paul
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1995
Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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Interleukin 5 (IL-5) is a cytokine mainly produced by activated T cells upon stimulation with antigen, and by mast cells upon stimulation with allergen/IgE complex or calcium ionophores [1,2]. The study of murine (m) IL-5 originated in the search for T-cell-replacing factor (TRF), which induces 2,4-dinitrophenyl (DNP)-primed B cells to differentiate ...
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Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin-5 (IL-5) is a glycoprotein with molecular weight 40 to 50 kDa that consists of homodimer. The murine cDNA encodes 133 amino acids with a signal sequence of 18 amino acids. The human cD NA codes for a protein with 134 amino acids in which the first 19 are the predicted signal sequence.
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Interleukin 5 and B cell differentiation
Cytokine & Growth Factor Reviews, 1998Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells and eosinophils. IL-5 receptor (IL-5R) comprises alpha and (beta)c chains. IL-5 specifically binds to IL-5Ralpha and induces the recruitment of (beta)c to IL-5Ralpha. JAK2 and JAK1 tyrosine kinases are constitutively associated with hIL-5Ralpha and (beta)c, respectively and ...
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The biological role of interleukin 5
The International Journal of Cell Cloning, 1990Eosinophilia can be a specific cellular response, but the mechanisms of its control are not yet fully understood. Interleukin 5 (IL-5) is a lineage-specific eosinophil differentiation and activation factor. It can be detected in the serum of mice with eosinophilia, and antibody to IL-5 blocks the development of parasite-induced eosinophilia.
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