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Interleukin 6: friend or foe in diabetic nephropathy? [PDF]

Archives of Medical Science
Introduction This study aimed to investigate the relationship between serum cytokine levels, particularly interleukin 6 (IL-6), and diabetic nephropathy (DN) in patients with type 1 (T1D) and type 2 diabetes (T2D). Material and methods A cross-sectional
Renad M. Alhamawi, Walaa Mohammedsaeed, Maha Aljumaa   +2 more
doaj   +2 more sources

Interleukin-6 Promoter Haplotypes and Interleukin-6 Cytokine Responses [PDF]

Shock, 2003
Genetic variations contribute to differences in the inflammatory response and are markers for disease risk and outcomes. We studied three single-nucleotide polymorphisms (-597 G-->A, -572 G-->C, and -174 G-->C) in the IL-6 promoter to determine associations with ex vivo LPS-stimulated IL-6 production by leukocytes.
Fernando A, Rivera-Chavez, Dixie L, Peters-Hybki, Robert C, Barber, Grant E, O'Keefe   +3 more
openaire   +2 more sources

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Lukas Zanders, Melanie Kny, Alexander Hahn, Sibylle Schmidt, Sebastian Wundersitz, Mihail Todiras, Ines Lahmann, Arnab Bandyopadhyay, Tobias Wollersheim, Lars Kaderali, Friedrich C. Luft, Carmen Birchmeier, Steffen Weber‐Carstens, Jens Fielitz   +13 more
doaj   +1 more source

Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

Mediators of Inflammation, 2006
The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers ...
Daria Simcic, Sonja Pezelj-Ribaric, Renata Gržic, Jelena Horvat, Gordana Brumini, Miranda Muhvic-Urek   +5 more
doaj   +2 more sources

Correlation Between Interleukin 6 and Interleukin 10 in Acute Myocardial Infarction

Biomolecules & Biomedicine, 2009
The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor α (TNF-α) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial ...
Larisa Dizdarević-Hudić, Zumreta Kušljugić, Fahir Baraković, Selmira Brkić, Damir Sabitović, Elmir Jahić, Maida Isabegović, Elnur Smajić, Igor Hudić, Katarina Divković   +9 more
doaj   +1 more source

Management of patients with rheumatoid arthritis in real clinical practice: Switching from interleukin 6 receptor inhibitors to interleukin 6 inhibitor (olokizumab)

Научно-практическая ревматология, 2023
Aim. Switching to another biologic with the same mode of action provides greater opportunity for long-term management of patients with rheumatoid arthritis (RA).
A. A. Baranov, I. B. Vinogradova, O. N. Anoshenkova, O. V. Antipova, E. A. Bogdanova, Y. Y. Grabovetskaya, E. P. Ilivanova, A. N. Kalyagin, I. N. Kushnir, N. A. Lapkina, M. V. Mokrousova, O. B. Nesmeyanova, N. M. Nikitina, P. A. Shesternya, N. V. Yudina, E. Feist, E. L. Nasonov   +16 more
doaj   +1 more source

Salivary Interleukin 6 and Sialic acid in Periodontitis

Brazilian Journal of Oral Sciences, 2018
Aim: Periodontitis is the major multi –factorial chronic infectious oral diseases in dentate people. Sialic acid regulates innate immunity response that release cytokines.
Jwan Ibrahim Jawzali
doaj   +1 more source

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

Human Vaccines & Immunotherapeutics, 2020
The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja, Sonia P. Chothani, Stuart A. Cook   +2 more
doaj   +1 more source

Cardiometabolic risk factors and their relationship with the interleukin-6 receptor gene polymorphism (rs2228145) in patients with hypertrophic cardiomyopathy

Российский кардиологический журнал, 2020
Aim. To analyze associations of interleukin-6 receptor gene (IL6R) polymorphism (rs2228145) with the clinical course characteristics of hypertrophic cardiomyopathy (HCM) in groups of patients with various cardiometabolic risk factorsMaterial and methods.
T. G. Bezhanishvili, A. Ya. Gudkova, V. G. Davydova, S. E. Andreeva, A. N. Krutikov, E. N. Semernin, B. N. Kudryavtsev, S. A. Pyko, A. A. Kostareva, E. N. Shlyakhto   +9 more
doaj   +1 more source

Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats [PDF]

Avicenna Journal of Phytomedicine
Objective: The use of flavonoids is increasing due to their costeffectiveness and less adverse reaction. Therefore, the effect ofapigenin on lipopolysaccharide (LPS)-induced inflammation wasinvestigated by measuring IL-1b, IL-6, and TNF-a, of serum in ...
Mohammad Sofiabadi
doaj   +1 more source