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Interleukin-10 and the Interleukin-10 Receptor
Annual Review of Immunology, 2001Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses.
K W, Moore +3 more
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Progress in Growth Factor Research, 1992
Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
D, Rennick, D, Berg, G, Holland
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Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the ...
D, Rennick, D, Berg, G, Holland
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1995
In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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In the 5 years since its discovery, the pleiotropic cytokine IL-10 has been shown to play an important role in the regulation of lymphoid and myeloid cells. IL-10 was detected independently in several laboratories. Fiorentino et al. [1] described a cytokine secreted by ‘type 2’ murine helper T-cell clones which inhibited cytokine production by ‘type 1’
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Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease
Current Allergy and Asthma Reports, 2012Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (
Shah, Neil +3 more
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Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus
Clinical Rheumatology, 2013Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by excessive production of a variety of autoantibodies, accumulation of immune complexes, and multiple organ systems involvement. Interleukin-10 (IL-10) has an important role in the growth, survival, differentiation, and function of B cells.
Hui, Peng +5 more
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The interleukin-10 family of cytokines
Trends in Immunology, 2002A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence paralogs, including IL-19, IL-20, IL-22 [IL-10-related T-cell-derived inducible factor (IL-TIF)], IL-24 [melanoma differentiation-associated antigen 7 (MDA-7)] and IL-26 (AK155).
Helmut, Fickenscher +5 more
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Biological properties of interleukin 10
Journal of Clinical Immunology, 1992Interleukin 10 (IL-10) was discovered in 1989 by Mosmann and colleagues as an activity produced by murine type 2 helper T cells which suppressed cytokine production by type 1 helper T cells (1). This activity, initially designated cytokine synthesis inhibitor factor (CSIF), was isolated by expression cloning by Moore and colleagues (2), who ...
M, Howard +4 more
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Regulation of Interleukin-10 Expression
2016Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota.
Sascha, Rutz, Wenjun, Ouyang
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