Results 261 to 270 of about 716,507 (306)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Viral vector-mediated interleukin 10 for gene therapy on chronic pain. [PDF]

Mol Pain
Kanao-Kanda M, Kanda H, Liu S, Kawamata T, Candiotti KA, Hao S.   +5 more
europepmc   +1 more source

TIM-3 ameliorates host responses to Salmonella infection by controlling iron driven CD4⁺ T cell differentiation and interleukin-10 formation. [PDF]

EBioMedicine
Pfeifhofer-Obermair C, Brigo N, Volani C, Tymoszuk P, Demetz E, Engl S, Weiss G.   +6 more
europepmc   +1 more source

Microglial Histaminergic Signaling Promotes Interleukin-10 Production and Ameliorates Motor Dysfunction in Parkinson's Disease. [PDF]

Aging Dis
Wang Y, Zhao M, Li L, Liu X, Lang L, Zhang X, Qi Z.   +6 more
europepmc   +1 more source

Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. [PDF]

Mucosal Immunol
Li J, Jacobse J, Pilat JM, Kaur H, Gu W, Kang SW, Rusznak M, Huang HI, Barrera J, Oloo PA, Roland JT, Hawkins CV, Pahnke AP, Khalil M, Washington MK, Wilson KT, Williams CS, Peebles RS, Konnikova L, Choksi YA, Hammer GE, Lau KS, Goettel JA.   +22 more
europepmc   +1 more source

A study on the distribution of interleukin-10 gene polymorphisms and their association with febrile seizure susceptibility in children from the Wenzhou region, Zhejiang Province. [PDF]

Front Public Health
Lu L, Huang H, Ding Z, Lin Z, Lv X, Gan T.   +5 more
europepmc   +1 more source

Interleukin-10

Current Opinion in Immunology, 1992
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure
R, de Waal Malefyt, H, Yssel, M G, Roncarolo, H, Spits, J E, de Vries   +4 more
core   +7 more sources

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Interleukin-10

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006
Interleukin (IL)-10, initially described as cytokine synthesis inhibitory factor, is a pleotropic cytokine produced by many cell populations. Its main biological functions appear to be quite diverse: on the one hand it is involved in the limitation and termination of inflammatory responses and the regulation of differentiation and proliferation of ...
K. Asadullah, R. Sabat, M. Friedrich, W. D. Docke, H. D. Volk, W. Sterry   +5 more
  +5 more sources

Interleukin-10

Annual Review of Immunology, 1993
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector ...
K W, Moore, A, O'Garra, R, de Waal Malefyt, P, Vieira, T R, Mosmann   +4 more
openaire   +3 more sources

Interleukin-10

BioDrugs, 1997
Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine secreted by several cell types. Most anti-inflammatory effects of IL-10 are caused by its ability to deactivate macrophages and monocytes, whereas its immunosuppressive properties are due to functional inhibition of both antigen-presenting cells and T cells.
Goldman, Michel, Velu, Thierry, Pretolani, M.   +2 more
  +7 more sources