Results 11 to 20 of about 981,818 (305)

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

Frontiers in Immunology, 2023
BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, it is
Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wróblewska, Marta Świtalska, Tomasz M. Goszczyński, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka   +8 more
doaj   +1 more source

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

mSphere, 2018
It has previously been shown that genital tract infection with Neisseria gonorrhoeae in mice does not induce a state of protective immunity against reinfection but instead suppresses the development of adaptive immune responses against N.
Yingru Liu, Julianny Perez, Laura A. Hammer, Heather C. Gallagher, Magdia De Jesus, Nejat K. Egilmez, Michael W. Russell   +6 more
doaj   +1 more source

Tumor cell-based vaccine contributes to local tumor irradiation by eliciting a tumor model-dependent systemic immune response

Frontiers in Immunology, 2022
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold.
Tinkara Remic, Tinkara Remic, Gregor Sersa, Gregor Sersa, Kristina Levpuscek, Kristina Levpuscek, Ursa Lampreht Tratar, Ursa Lampreht Tratar, Katja Ursic Valentinuzzi, Katja Ursic Valentinuzzi, Andrej Cör, Andrej Cör, Urska Kamensek, Urska Kamensek   +13 more
doaj   +1 more source

Comparison of LPS-stimulated release of cytokines in punch versus transwell tissue culture systems of human gestational membranes [PDF]

, 2010
Background Cytokine signaling within the amnionic, chorionic and decidual extraplacental gestational membranes plays an important role in membrane rupture and the timing of birth.
Loch-Caruso, Rita, Miller, Mark F.
core   +4 more sources

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

OncoImmunology, 2021
Recent advances in immunotherapy, as a part of the multidisciplinary therapy, has gradually gained more attention. However, only a small proportion of patients who sensitive to the therapy could gain benefits.
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo   +7 more
doaj   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
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Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

Factors Associated With In Vitro Interferon-gamma Production in Tuberculosis

Journal of the Formosan Medical Association, 2011
Macrophage activation assisted by interferon-gamma (IFN-γ) is a primary mechanism by which Mycobacterium tuberculosis is killed, but IFN-γ (production is inhibited in tuberculosis (TB) patients. The production of IFN-γ is influenced by many factors, such
Chung-Chieh Yu, Yu-Chih Liu, Chien-Ming Chu, Duen-Yau Chuang, Wen-Chen Wu, Huang-Pin Wu   +5 more
doaj   +1 more source

Interleukin (IL)–12 and IL-23 Are Key Cytokines for Immunity against Salmonella in Humans [PDF]

, 2004
Patients with inherited deficiency of the interleukin (IL)–12/IL-23–interferon (IFN)–g axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such
Casanova, Jean-Laurent, Dorman, Susan E, Fieschi, Claire, Holland, Steven M, Kumararatne, Dinakantha S, Lammas, David A, MacLennan, Calman A., MacLennan, Jenny M, Ottenhoff, Tom H. M, Picard, Capucine, Sanal, Ozden   +10 more
core   +1 more source