Results 201 to 210 of about 986,782 (400)

Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages

, 2004
Qi Luo, Xiaojing Ma, Sharon M. Wahl, James J. Bieker, Merlin Crossley, Luis J. Montaner   +5 more
openalex   +1 more source

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Proceedings of the National Academy of Sciences of the United States of America, 1996
D. Klinman, A. Yi, S. Beaucage, J. Conover, A. Krieg   +4 more
semanticscholar   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Sydenham Chorea With Elevated Interleukin-12 Levels Responsive to Plasmapheresis and Immunotherapy. [PDF]

Cureus
Xu Z, Rosenberg J, Fekete R, Thomas AM.
europepmc   +1 more source

Mycobacterium tuberculosisLipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages

, 2004
Dee N. Dao, Laurent Kremer, Yann Guérardel, Alberto Molano, William R. Jacobs, Steven A. Porcelli, Volker Briken   +6 more
openalex   +2 more sources

Inhibition of the Defense System Stimulating Interleukin-12 Interferon-γ Pathway During Critical Illness [PDF]

, 1997
Wolfgang Ertel, Marius Keel, Regula Neidhardt, Ursula Steckholzer, Jean-Pierre Kremer, Udo Ungethuem, O. Trentz   +6 more
openalex   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

A Phase II Study of Docetaxel and Pembrolizumab plus Interleukin 12 Gene Therapy in Nonmetastatic, Anthracycline-Refractory Triple-Negative Breast Cancer (INTEGRAL). [PDF]

Clin Cancer Res
Niravath P, Uzair I, Sun K, Mai H, Guan J, Li M, Deng J, Qian W, Zhou J, Guzman L, Banaglorioso K, Hashmani R, Mathur S, Chang J.   +13 more
europepmc   +1 more source

Gene gun–mediated oral mucosal transfer of interleukin 12 cDNA coupled with an irradiated melanoma vaccine in a hamster model: Successful treatment of oral melanoma and distant skin lesion [PDF]

, 2001
Jun Wang, Takashi Murakami, Yoji Hakamata, Takashi Ajiki, Yoshinori Jinbu, Yoko AKASAKA, Mamitaro Ohtsuki, Hidemi Nakagawa, Eiji Kobayashi   +8 more
openalex   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source