Results 211 to 220 of about 986,782 (400)

Efficacy of interleukin-12/23 and interleukin-23 inhibitors in Hailey-Hailey disease. [PDF]

JAAD Case Rep
Echeandia-Francis C, Jiang X, Mortlock RD, Goldust M, Milstone LM, Choate KA.   +5 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Osteopontin promoted cardiac inflammation through increased interleukin-12 in acute myocarditis. [PDF]

Mol Biomed
Nie X, Fan J, Qin Y, Wen J, Lu Z, Chen C, Wang DW.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Interleucina-12 exógena evita disminución de actividad de mieloperoxidasa de macrófagos en gérbiles con esporotricosis

Revista Cubana de Investigaciones Biomédicas
Introducción: la interleucina-12 es una citosina inmunorreguladora con múltiples funciones biológicas, incluyendo la activación de macrófagos. La mieloperoxidasa es una enzima que desempeña un papel importante en la función antimicrobiana de fagocitos ...
Aurelio Flores-García, Rogelio Sánchez-Gutiérrez, Raymundo Velasco-Rodríguez, Alejandro Zambrano-Parra, Salvador Ruiz-Bernés, Cecilio Paredes Estrada   +5 more
doaj  

Combined Treatment with Interleukin-12 and Indomethacin Promotes Increased Resistance in BALB/c Mice with EstablishedLeishmania majorInfections

, 2002
Jian Li, Udaikumar M. Padigel, Phillip Scott, Jay P. Farrell   +3 more
openalex   +2 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Phase II Trial of Interleukin-12 Followed by Interferon Alfa-2b in Patients with Metastatic Malignant Melanoma: Results from CALGB 500001 (Alliance). [PDF]

Cancer Immunol Res
Liu A, Johnson C, Niedzwiecki D, Relation T, Yarlagadda SV, Gajewski TF, Carson WE.   +6 more
europepmc   +1 more source

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

, 1993
Catherine S. Tripp, S F Wolf, Emil R. Unanue   +2 more
openalex   +2 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source