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Tumor-Localized Interleukin-2 and Interleukin-12 Combine with Radiation Therapy to Safely Potentiate Regression of Advanced Malignant Melanoma in Pet Dogs. [PDF]

Clin Cancer Res
Stinson JA, Barbosa MMP, Sheen A, Momin N, Fink E, Hampel J, Selting KA, Kamerer RL, Bailey KL, Wittrup KD, Fan TM.   +10 more
europepmc   +1 more source

Antitumor properties of traditional lactic acid bacteria: Short-chain fatty acid production and interleukin 12 induction. [PDF]

Heliyon
Mobasherpour P, Yavarmanesh M, Edalatian Dovom MR.   +2 more
europepmc   +1 more source

Oncolytic varicella-zoster virus engineered with ORF8 deletion and armed with drug-controllable interleukin-12. [PDF]

J Immunother Cancer
Jiang H, Nace R, Carrasco TF, Zhang L, Whye Peng K, Russell SJ.   +5 more
europepmc   +1 more source

CATE 12

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Immunoregulation by interleukin-12

Journal of Leukocyte Biology, 1996
Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is stimulated by bacteria, bacterial products, and intracellular parasites and enhanced by priming with granulocyte-macrophage colony-stimulating factor (CM-CSF)
G, Trinchieri, F, Gerosa
openaire   +2 more sources

Interleukin-12

Journal of Leukocyte Biology, 1994
Abstract Interleukin-12 (IL-12) is a newly characterized cytokine that has a unique heterodimeric structure. It was initially cloned from B lymphoblastoid cell lines, but the majority of IL-12 is produced by macrophages/monocytes following appropriate stimulation. IL-12 can (1) enhance the cytolytic activity of a number of effector cells
openaire   +2 more sources

Interleukin-12 and interleukin-16 in periodontal disease

Cytokine, 2005
The immune system plays an important role in the pathological process of periodontitis. Interleukin-12 (IL-12) is produced by monocytes, macrophages and neutrophils. These cells are proinflammatory infiltrates in periodontitis tissues. High IL-12 will contribute to the immune reaction to Th1 type. IL-12 is an inducer of INF-r production.
I-San, Tsai, Chi-Cheng, Tsai, Ya-Ping, Ho, Kun-Yen, Ho, Yi-Min, Wu, Chun-Cheng, Hung   +5 more
openaire   +2 more sources

lnterleukin-12

International Archives of Allergy and Immunology, 2009
Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
openaire   +2 more sources

Molecular characterization of interleukin 12

Archives of Biochemistry and Biophysics, 1992
Interleukin 12 (IL-12), formerly known as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory factor, is a cytokine secreted by a human B lymphoblastoid (NC-37) cell line when induced in culture with phorbol ester and calcium ionophore. This factor has been purified to homogeneity and shown to synergize with low concentrations of
F J, Podlaski, V B, Nanduri, J D, Hulmes, Y C, Pan, W, Levin, W, Danho, R, Chizzonite, M K, Gately, A S, Stern   +8 more
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