Results 231 to 240 of about 986,782 (400)

Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection.

, 1996
Kazunori Kato, Osamu Shimozato, Kazuto Hoshi, Hiroaki Wakimoto, Hirotaka Hamada, H Yagita, K Okumura   +6 more
openalex   +1 more source

Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency.

Clinical Infectious Diseases, 2014
M. Ouederni, O. Sanal, A. Ikinciogulları, I. Tezcan, F. Doğu, Ithaisa Sologuren, S. Pedraza-Sánchez, M. Keser, G. Tanır, C. Nieuwhof, E. Colino, D. Kumararatne, J. Levy, N. Kutukculer, C. Aytekin, Estefanía Herrera-Ramos, Micah M. Bhatti, N. Karaca, R. Barbouche, A. Broides, E. Goudouris, J. Franco, N. Parvaneh, I. Reisli, A. Strickler, A. Shcherbina, A. Somer, A. Segal, A. Ángel-Moreno, José L Lezana-Fernández, M. Bejaoui, M. Bobadilla-Del Valle, S. Kachboura, T. Sentongo, I. Ben‐Mustapha, J. Bustamante, C. Picard, A. Puel, S. Boisson-Dupuis, L. Abel, J. Casanova, C. Rodríguez-Gallego   +41 more
semanticscholar   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Interleukin 12/23 and interleukin 23 inhibitors for moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis. [PDF]

Ann Gastroenterol
Sawaf B, Hayek MA, Kassem A, Alsoud D, Alom M, Salam AH, Shembesh RH, Beshr MS, Hallak Y, Abbarh S, Batikh E, Shibani M, Elhadi M, Alastal Y, Regueiro M.   +14 more
europepmc   +1 more source

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.

Cold Spring Harbor Perspectives in Biology, 2018
Juming Yan, M. Smyth, M. Teng
semanticscholar   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Improved Antitumor Activity of Interleukin-12-Secreting Chimeric Antigen Receptor T Cells Targeting CD176 across Different Carcinomas. [PDF]

Transfus Med Hemother
Umland M, Dragon AC, Beermann LM, Bonifacius A, Kehler P, Gellert J, Blasczyk R, Abken H, Schambach A, Hudecek M, Eiz-Vesper B.   +10 more
europepmc   +1 more source

Antitumor Activities of Interleukin-12 in Melanoma. [PDF]

Cancers (Basel), 2022
Gao W, Pan J, Pan J.
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial. [PDF]

Nat Commun
Park JC, Curti B, Butler M, Wehrenberg-Klee E, Elassal J, Tighe R, Battula S, Iodice G, Kaufman HL, Kirkwood JM.   +9 more
europepmc   +1 more source